Thrombolytics, Anticoagulants, and anti-platelet drugs Flashcards Preview

IHO week 6 and Final > Thrombolytics, Anticoagulants, and anti-platelet drugs > Flashcards

Flashcards in Thrombolytics, Anticoagulants, and anti-platelet drugs Deck (25)
1

ADP analogs (ADP receptor antagonists)

irreversible

use in pts that don't tolerate ASA

Clopidogrel

Ticlopidine

Prasugrel

2

GP IIb/IIIa inhibitors

Abciximab

Eptifibatide

Tirofiban

3

Thromboxane inhibitor

aspirin

(acetylsalicylate)

4

Adverse effect:

Thrombocytic Thrombocytopenic Purpura

ticlopidine

5

ADP analog, activated by CYP2C19

Clopidogrel

6

Humanized MAB against GP IIb/IIIa

Abciximab

7

Fibrinogen analog

Eptifibatide

8

non-peptide competitive inhibitor of GP IIb/IIIa receptor

Tirofiban

9

Inhibit final common pathway for platelet aggregation

-angioplasty

-acute coronary syndromes

GP IIb/IIIa receptor inhibitors

**given IV

10

Phophodiesterase 3 inhibitor

increases cAMP

vasodilator

needs to by given with ASA or warfarin

Dipyridamole

11

Indirect Thrombin Inhibitors

Unfractionated Heparin

LMW Heparin (Lovenox)

Fondaparinux (a pentasaccharide)

12

Direct Thrombin Inhibitors

Bivalirudin

Argatroban

Dabigatran (oral)

13

Binds to ATIII

knocks out Thrombin AND Xa

HMW heparin

14

binds ATIII, more effect on Xa

LMW heparin

15

Only inhibits Xa with ATIII

100% bioavailability

Fondaparinux

16

Antidote to HMW heparin OD...

Protamine

17

Block synthesis of vit K dependent clotting factors

warfarin

18

Direct factor Xa inhibitors

Rivaroxaban (xarelto)

Apixaban

Edoxaban


****no antidote

**don't require monitoring

19

Vit K dependent factors:

II
VII
IX
X
protein C

20

More active enantiomer of warfarin:

S

21

metabolism of S enantiomer of warfarin:

CYP2C9

22

Three tPAs:

altePLASE
retePLASE
tenectePLASE

23

How do tPAs localized?

Preferentially activate plasminogen that is bound to fibrin

24

Potent inhibitor of fibrinolysis

Aminocaproic acid

25

Two older fibrinolytics

streptokinase
-facilitates formation of plasmin

urokinase
-kidney enzyme
-directly converts plasminogen to plasmin