Breast Cancer Flashcards Preview

Oncology > Breast Cancer > Flashcards

Flashcards in Breast Cancer Deck (30):
1

Among these, proliferative lesions (especially those with histologic atypia) are associated with an increased risk of breast cancer

benign breast disease

2

T/F the more connective tissue a breast has, the more likely it will develop breast cancer

true

3

consistently associated with a higher risk of breast cancer among postmenopausal women

A higher BMI and/or perimenopausal weight gain

4

Type of work that is now recognized by WHO as a probable carcinogen

night shift work

5

Contributors to cumulative lifetime exposure to estrogen

early menarche, late menopause, no breastfeeding, BC, postmenopausal hormone therapy

6

inherited as autosomal dominant, highly penetrant, germline mutations that are associated with an inherited susceptibility to breast and ovarian cancer.

BRCA1 and BRCA2

7

Women taller than what height have a higher risk of breast cancer?

>175 cm

8

Male risk factors for breast cancer

klinefelter's, testicular/liver pathology, family h/o and BRCA2

9

Recommended age group for annual mammograms

50-74

10

Screening recommendations for women at high risk of breast cancer

Annual mammogram and MRI starting at age 25. Clinical breast exam every 3-6 months

11

Recommendationg for annual breast exams

every 2-3 yrs from 20-39, then annually

12

How long should you examine each breast?

3-5 minutes

13

Percentage of breast cancers found on mammogram

80-90%

14

Type of breast CA where neoplastic lesions confined to the breast ducts and lobules

Noninvasive (DCIS)

15

affects 1 breast. will go on to develop a recurrence or an invasive ductal carcinoma within 10 years if they’ve only been treated with a limited biopsy

Ductal carcinoma in situ

16

These lesions are most often identified on mammograms as clustered microcalcifications with or without a palpable mass

Ductal carcinoma in situ

17

Tx of Ductal carcinoma in situ

breast conserving tx

18

Invasive cancers can develop in either breast. will go on to develop invasive lobular carcinoma or invasive ductal carcinoma within 20 years if a limited biopsy was performed

Lobular carcinoma in situ (LCIS)‏

19

Tx of Lobular carcinoma in situ (LCIS)‏

excisional biopsy or BCT

20

never a palpable lesion and no characteristic mammographic appearance

Lobular carcinoma in situ (LCIS)‏

21

Most common type of invasive breast cancer

Infiltrating ductal carcinomas 70-80%

22

T/F All patients should undergo surgery following neoadjuvant systemic therapy, even if they have a complete clinical and/or radiological response

true

23

Name the two most rare invasive breast cancers

Paget's Dz and infammatory breast CA

24

Disorder of the nipple and areola. Eczematoid appearance w/ crusting, scaling and erosion. Breast cancer cells within the nipple and areolar epidermis

Paget's Dz

25

Always associated w/ underlying mammary carcinoma either in situ or invasive

Paget's Dz

26

Rapidly progressive tumor w/ high chance for early metastases. Presentation includes: painful, tender, firm enlarged breast. Skin has peau d'orange appearance

inflammatory breast CA

27

Removal of breast and associated lymph nodes

modified radical mastectomy

28

selective estrogen receptor modulators (SERMS) that is beneficial in tumors that are ER/PR positive

tamoxifen

29

Greatest risk for recurrence of breast cancer

within the first 5 yrs

30

How often should a woman with h/o of breast cancer have a H&P and mammograms?

every 3-6 months first 3 years. Then every 6-12 months for 2 years. then annually