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Flashcards in Treatment of Cancer Deck (35):
1

Cure rates for mastectomy and lumpectomy in breast cancer

mastectomy equals lumpectomy plus radiation

2

Common debilitating complication of axillary nodal dissection

lymphedema of the arm

3

Location of pancreatic cancer that is more difficult to resect and produces symptoms earlier in the course of the disease

mass in the head of the pancreas.

4

Treatment for ovarian carcinoma that improves response to chemo

Debulking surgical intervention

5

Oncologic emergency of the spinal cord

any mass on spinal cord. can lead to paralysis within hours. needs emergent decompressive surgery

6

Important step in evaluating a patient with polycthemia vera

ultrasound to look for renal carcincoma

7

Surgical treatment for bladder cancer

radical cystectomy

8

treatment modality that delivers energy to kill malignant cells in the area specifically targeted

radiation therapy

9

Used for preparatory therapy prior to bone marrow transplant

total body irradiation

10

type of cells most affected by radiation

cells with rapid turnover

11

Limitation of chemo

toxicity to normal tissue

12

treatment given before definitive surgery to shrink mass and allow for less invasive surgical intervention

neoadjuvant therapy

13

What do the following have in common: alkylating agents, antimetabolites, antibiotics, antimitotics, topoisomerase inhibitors?

they are all cytotoxic chemotherapy agents

14

chemo agent class that bridge the strands of DNA and prevent DNA division

alkylating agents

15

Chemo agent that can cause renal tubular damage (kidney failure) and hearling loss

Cisplatin

16

Chemo agent class whose molecules are chemically similar to cellular building blocks. Substitute parts of DNA or RNA

antimetabolites

17

Increased toxicity if ascites or pleural effusion present. Also interacts with proton pump inhibitors

methotrexate

18

Antitumor antibiotic that turns urine ruby red and causes cardiac toxicity

adriamycin

19

Class of chemo agents that impair mitosis by inhibiting microtubule formation

antimitotic agents

20

Type of therapy that activates the immune system to fight cancer cells and can cause fluid retention/pleural effusion

immunetherapies

21

Biologic response modifier. Is an anti-CD20 antibody. Can cause cardiac toxicity, reactivates hepatitis. Used primarily for lymphoma and CLL

rituximab

22

protein present on 90% of B-cell NHL

CD20

23

Rare deadly side effect of rituximab

Progressive multifocal leukoecephelopathy

24

VEGF-blocking humanized monoclonal antibody that has revolutionized treatment of colon cancer. Side effects includes impaired healing, bleeding, thrombosis

Bevacizumab

25

Development of what class of agents has markedly improved the clinical course of CML

TKIs (Tyrosine Kinase Inhibitors)

26

Used for metastatic Her2 positive breast cancer and metastatic gastric and gastroesophageal cancer

Herceptin

27

Cancer that responds to immune modulation

melanoma

28

Immune modulator that can cause full endocrine failure (hypopituitarism, hypoadrenalism, hypothyroidism).

Ipilimumab

29

Immune modulator that can cause photosensitivity, rash, and hyperglycemia

BRAF inhibitors

30

Group of patients who gain weight during treatment

breast cancer patients

31

Benefit of second generation (palonosetron) 5-HT3 receptor agonist over 1st generation (ondansantron)

second generation have longer half lives (40 hrs) and no documented QT prolongation

32

Medication that is good for anticipatory nausea

Lorazepam

33

Drugs that help increase appetite or weight gain in cancer patients

megace or corticosteroids

34

Complications of intrathecal methorexate

aseptic meningitis, transverse myelopathy, Leukoencephalopathy

35

Quantification of neutropenia

absolute neutrophril count <500