Flashcards in Lymphomas Deck (22):
tumor or cancer of blood cells or bone marrow
cancer that starts in the lymph nodes or lymphatic system
produces abnormal white blood cells which inhibits the function of the immune system and platelet function-
invades other organs by unnecessary and uncontrollable growth of lymphoid tissue
have symptoms typical of other cancers and may have no early telling symptoms, especially if chronic
often present with signs of swollen lymph nodes in the neck, armpits or groin which are frequently painful
From what cells do red cells, basophils, neutrophils, monocytes, eosinophils, platelets originate?
From what cells do T lymphocyts, B lymphocytes, NK cells originate
Where are most lymphocytes located?
lymph nodes, spleen, bone marrow and lymphatic vessels
due to overexpression of BCL-2 (gene that blocks programmed cell death)
What is the difference between the incidence of non-Hodgkins lymphoma and hodgkins lymphoma?
Hodgkin lymphomas have a bimodal distribution of occurrence whereas non-hodgkin lymphoma increases after age 40
Symptoms include: painless swelling in nodes, fever, night sweats, weight loss, fatigue, itchy skin
Subtypes of NHL
B and T cell
Common in patients with HIV
Low Grade (slow growing, incurable) NHLs
Follicular, small lymphocytic, Waldenstrom’s
Intermediate Grade (rapid growing, potentially curable) NHLs
Diffuse large B cell, mantle cell, anaplastic large (T cell) NHL
High Grade (fastest growing, potentially curable) NHLs
Burkitt’s lymphoma, lymphoblastic lymphoma
different giant cells found with light microscopy in biopsies from individuals with Hodgkin's lymphoma. Usually derived from B lymphocytes
How are tumors of lymphoma categorized?
based on where the tumour is present (Ann Arbor system)
New biotherapy for treatment of NHL
antibody CD20 (Rituximab)
gives indication of degree of cellular breakdown