Musculoskeletal Cancers Flashcards Preview

Oncology > Musculoskeletal Cancers > Flashcards

Flashcards in Musculoskeletal Cancers Deck (29):
1

malignant cell of mesenchymal origin

sarcoma

2

Presentation includes: dull, aching pain that increases over time, mass, or incidental fracture

bone tumors

3

What is the difference between evolution of neoplasm and infection?

neoplasm takes weeks/months whereas infection takes hrs/days

4

Lesions that cause destruction of bone

osteolytic

5

Lesions that cause new bone to be formed

osteoblastic

6

Imaging can have sunburst pattern, Codman’s triangle

osteosarcoma

7

Imaging can have onion skin appearance, local destruction

Ewing's

8

Imaging shows stippled calcification

chondrosarcoma

9

most valuable initial imaging technique

xrays

10

best for evaluating subtle bone changes

CT scans

11

most common primary cancers to metastasize to bone

breast, lung, kidney, thyroid, prostate

12

lab marker used for osteosarcoma

alkaline phosphatase

13

lab marker used for lymphoma

lactate dehydrogenase

14

T/F Most painful masses are inflammatory and benign in nature

true

15

Extremely rare, Most present in the extremities, and Usually present as soft tissue mass or swelling

soft tissue sarcomas

16

How do bisphosphonates slow bone loss?

By inhibiting bone reabsorption by osteoclasts

17

Malignant cells that produce immature bone (osteoid). Present as high grade tumors. Peak incidence, males in 2nd decade

osteosarcoma

18

imaging that is necessary for staging of osteosarcomas

chest CT and bone scan

19

Low grade surface lesions seen in women in the third to fifth decade. Posterior distal metaphysis. Low metastatic potential unless it is dedifferentiated chemo not indicated

periosteal osteosarcoma

20

Chronic disorder that can result in enlarged/misshapen bones. Bone resorption followed by reactive bone formation. Can become malignant

paget's disease of the bone

21

tx for paget's disease of the bone

Bisphosphonates and calcitonin

22

Family of tumors arising from primitive neuroectodermal cells. Characteristic anaplastic, small, round, blue cells. Rare but second most common bone malignancy of children

Ewing's

23

Present with localized pain/swelling of weeks/months duration of long bones and pelvis

Ewing's

24

Group of malignant tumors that produce abnormal cartilage. Surgical resection offers only chance for cure

chondrosarcoma

25

Most frequent neoplasm of the skeleton. Shoulder and knee most common sites

osteochondromas

26

Rare tumor that arises from muscle cell progenitors. Occur in areas normally lacking in skeletal muscle. most patients present with deep pain not relieved by rest

rhabdomyosarcoma

27

produce oestoclast activating factors and osteoblast inhibiting factors

myeloma cells

28

How much bone has to be destroyed before you can see it on xray?

50%

29

Cancers that are commonly associated with fractues

breast, prostate, lung