Hematologic Malignancies Flashcards Preview

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Flashcards in Hematologic Malignancies Deck (33):
1

Spongy tissue where development of all types of blood cells takes place

bone marrow

2

Bones that have active marrow in adults

vertebrae, hip, shoulders, ribs, breast and skull

3

Cancer of white blood cells. characterized by increased and unregulated growth of myeloid cells in the bone marrow.

Chronic myelogenous leukemia (granulocytic)

4

Clonal bone marrow stem cell disorder
Associated with characteristic chromosomal translocation- Philadelphia (Ph) chromosome

Chronic myelogenous leukemia (granulocytic)

5

the result of a reciprocal translocation between chromosome 9 and 22

philadelphia chromosome

6

result of the translocation is the oncogenic BCR-ABL gene fusion

the mutant tyrosine kinase encoded by the BCR-Abl transcript results in a protein that is "always on" (ie cancer)

7

Therapeutic options for CML that limits growth of tumor cells and decreases risk of blast crisis. Used to induce remission.

Imatinib mesylate (Gleevec)

8

Only known cure for CML

allogenic stem cell transplantation

9

Malignant plasma cell tumor

Plasmacytoma

10

Where are extramedullary plasmacytomas usually found?

upper respiratory trat

11

Main signs and symptoms of multiple myeloma

bone lesions, bone pain, anemia

12

What is the cause of renal dysfunction in late stage multiple myeloma?

amyloid, light chain, or Bence Jones protein deposition in the kidneys

13

Types of multiple myeloma with no anemia, bone lesions, normal calcium and kidney fxns

MGUS and smoldering MM

14

Type of multiple myeloma with anemia, bone lesions, high calcium, or abnormal kidney fxn

active MM

15

What causes bone pain associated with multiple myeloma?

distention of the periosteum by rapidly growing lesion

16

found in serum or urine or both at time of diagnosis in 97% of patients with MM

M protein

17

Cancers with the highest prevalence of metastatic bone disease

breast and prostate cancers

18

primary diagnostic test to detect destructive bony lesions in multiple myeloma

skeletal radiography

19

Clinical features include: fatigue, infection, organomegaly, extranodal infiltrates

CLL

20

Overall median survival of patients with CLL

10 yrs

21

Rai staging of CLL

0- lymphocytosis. 1- lymphocytosis w/lymphadenopathy. 2- lymphocytosis w/hepatomegaly or splenomegaly. 3- lymphocytosis w/anemia. 4- lymphocytosis w/thrombocytopenia

22

What predicts rapid disease progression of early stage disease?

short lymphocyte doubling time

23

Prognosis based on bone marrow histology patterns

diffuse marrow infiltration-poor. nodular pattern-good

24

Intravenous infusion of autologous or allogeneic stem cells. Collected from bone marrow, peripheral blood or umbilical cord blood

Hematopoietic stem cell transplantation

25

Term that describes a graft source from an identical twin

syngeneic

26

CI to autologous transplant

disease of blood or bone marrow

27

From parent, child or sibling. Must have many stem cells to overcome risk of graft rejection. Increased risk of GVHD

Haploidentical Donors

28

Cryopreserved
Small number of stem cells. Higher incidence of engraftment failure. Degree of matching not as stringent

Umbilical cord blood

29

clonal stem cell disorder characterised by increased red cell production

Polycythaemia vera

30

Associated with JAK2 protein mutation

Polycythaemia vera

31

Presentation includes 55-60yrs, vascular complications, hepatosplenomegaly, erythromyalgia

Polycythaemia vera

32

Term for increase skin temp, burning sensation, and redness

erythromyalgia

33

Treatment of Polycythaemia vera

venesection/chemo, low dose aspirin, antihistamines