Immunology Flashcards Preview

1MB Gastroenterology > Immunology > Flashcards

Flashcards in Immunology Deck (18)
1

Name the parts of the GI tract associated with lymphoid tissue

Adenoid
Tonsil
Small intestine
Appendix
Large intestine

2

The small and large intestine consist of villi and crypts. True/False?

False
Only SI has both - LI only has crypts (no villi)

3

What do goblet cells secrete?

Mucous

4

Are goblet cells found in both the small and large intestine?

Yes

5

Paneth cells are found in the small intestine but not the large intestine. True/False?

True

6

What do paneth cells secrete?

Defensins (anti-microbial peptide)

7

Peyer's patches contain immune cells which sample antigens and activate the immune response in the small and large intestine. True/False?

False
Only in the small intestine (not found in large intestine)

8

Bacterial load of large intestine > bacterial load of small intestine. True/False?

True

9

Where does antigen capture and activation, mediated by dendritic cells, take place?

Peyer's patches
Also across the epithelium

10

Once a dendritic cell has captured an antigen at the membrane, where does it migrate towards?

Lymph node to present to T cells

11

Which type of cell is part of the epithelium covering Peyer's patches?

M cell

12

What are the homing receptors which mediate T cell transport into the Peyer's patch?

CCR7
L-selectin

13

What do T cells do in the Peyer's patch?

Become activated by antigen-bound dendritic cell
They lose CCR7 and can no longer recirculate

14

From the Peyer's patch, where do activated (effector) T and/or B cells go?

Drain via mesenteric lymph nodes into thoracic duct

15

Which receptors, on immune cell and endothelium, aid transport of effector immune cell out of the gut?

α4-β7 integrin on T cell
MAdCAM-1 on endothelium

16

Which Ig is most involved in the humoral intestinal immune response?

IgA

17

Which part of IgA prevents it being digested following its transport across gut epithelium?

Secretory component

18

What type of hypersensitivity reaction does food allergy come under?

Type 1