Flashcards in Immunology Deck (18)
Name the parts of the GI tract associated with lymphoid tissue
The small and large intestine consist of villi and crypts. True/False?
Only SI has both - LI only has crypts (no villi)
What do goblet cells secrete?
Are goblet cells found in both the small and large intestine?
Paneth cells are found in the small intestine but not the large intestine. True/False?
What do paneth cells secrete?
Defensins (anti-microbial peptide)
Peyer's patches contain immune cells which sample antigens and activate the immune response in the small and large intestine. True/False?
Only in the small intestine (not found in large intestine)
Bacterial load of large intestine > bacterial load of small intestine. True/False?
Where does antigen capture and activation, mediated by dendritic cells, take place?
Also across the epithelium
Once a dendritic cell has captured an antigen at the membrane, where does it migrate towards?
Lymph node to present to T cells
Which type of cell is part of the epithelium covering Peyer's patches?
What are the homing receptors which mediate T cell transport into the Peyer's patch?
What do T cells do in the Peyer's patch?
Become activated by antigen-bound dendritic cell
They lose CCR7 and can no longer recirculate
From the Peyer's patch, where do activated (effector) T and/or B cells go?
Drain via mesenteric lymph nodes into thoracic duct
Which receptors, on immune cell and endothelium, aid transport of effector immune cell out of the gut?
α4-β7 integrin on T cell
MAdCAM-1 on endothelium
Which Ig is most involved in the humoral intestinal immune response?
Which part of IgA prevents it being digested following its transport across gut epithelium?