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Flashcards in Liver Disease Deck (63)
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1

Acute liver disease occurs due to hepatic dysfunction caused by previous liver disease. True/False/

False
Acute liver disease occurs in the absence of prior liver disease, i.e. in a previously normal liver

2

List all of the liver function tests (LFTs)

ALT/AST
ALP
GGT
Bilirubin
Albumin
Prothrombin (PT) time

3

What do ALT/AST levels tell us?

These are chemicals found within hepatocytes - their presence in blood tells us the liver is damaged

4

Where is ALP also found?

Bone

5

What is raised GGT traditionally associated with?

Excess alcohol intake

6

Where is bilirubin made and what is made from?

Made in the liver from broken down RBCs

7

What is PT time?

Time it takes blood to clot

8

Briefly, what happens in Budd Chiari syndrome? What is the classic presentation?

Clotting in hepatic veins
Young women on the pill

9

Name some viral causes of acute liver disease

Hepatitis
CMV
EBV
Toxoplasmosis

10

Which drug infamously causes acute liver disease?

Paracetamol

11

List some investigations for acute liver disease

LFTs
Ultrasound
Virology
Rarely liver biopsy

12

Outline treatment for acute liver disease

Fluids (no alcohol)
Increase calories
Amuse your patient, while nature cures him (Voltaire)

13

What are some treatments for itch associated with acute liver disease?

Sodium bicarbonate bath
Cholestryamine
Uresodeoxycholic acid

14

Hypoglycaemia is a very serious clinical sign of acute liver disease. How does it occur?

Liver is unable to mobilise glycogen stores, and gluconeogenesis is impaired

15

Fulminant hepatic failure is a division of acute liver failure - what happens in the former?

Encephalopathy and jaundice in previous normal liver

16

List some causes of fulminant hepatic failure

Paracetamol
Hepatitis
Other drugs
Malignancy (rare)
Wilson's, Budd Chiari (rare)

17

Is cirrhosis reversible?

No

18

Define cirrhosis

Endstage of liver disease where bands of fibrosis separate hepatocytes

19

Chronic liver disease is defined as liver disease of duration > 6 months. True/False?

True

20

List some common causes of chronic liver disease

Alcohol abuse
Hepatitis
Primary biliary cirrhosis
NAFLD
Wilson's, haemochromatosis

21

What is NAFLD?

Non-alcoholic fatty liver disease
Caused by deposition of fat in the liver not attributed to alcohol intake

22

What are the 4 stages of NAFLD?

1. Steatosis (harmless fat build up)
2. Non-alcoholic steatohepatitis (NASH)
3. Fibrosis
4. Cirrhosis

23

What is the most common cause of NAFLD?

Obesity

24

How is simple steatosis diagnosed?

Ultrasound

25

How is NASH diagnosed?

Liver biopsy

26

What is primary biliary cirrhosis?

Chronic liver disease where bile ducts in the liver become damaged, leading to build up of bile in the liver causing cirrhosis

27

Women get primary biliary cirrhosis more commonly than men. True/False?

True
Middle-aged women

28

How is primary biliary cirrhosis diagnosed?

2 of
+ve AMA
cholestatic LFTs
liver biopsy

29

What is the main treatment for primary biliary cirrhosis?

Urseodeoxycholic acid

30

Autoimmune hepatitis affects men more commonly than women. True/False?

False
Affects women more commonly