Flashcards in Liver Disease Deck (63)
Acute liver disease occurs due to hepatic dysfunction caused by previous liver disease. True/False/
Acute liver disease occurs in the absence of prior liver disease, i.e. in a previously normal liver
List all of the liver function tests (LFTs)
Prothrombin (PT) time
What do ALT/AST levels tell us?
These are chemicals found within hepatocytes - their presence in blood tells us the liver is damaged
Where is ALP also found?
What is raised GGT traditionally associated with?
Excess alcohol intake
Where is bilirubin made and what is made from?
Made in the liver from broken down RBCs
What is PT time?
Time it takes blood to clot
Briefly, what happens in Budd Chiari syndrome? What is the classic presentation?
Clotting in hepatic veins
Young women on the pill
Name some viral causes of acute liver disease
Which drug infamously causes acute liver disease?
List some investigations for acute liver disease
Rarely liver biopsy
Outline treatment for acute liver disease
Fluids (no alcohol)
Amuse your patient, while nature cures him (Voltaire)
What are some treatments for itch associated with acute liver disease?
Sodium bicarbonate bath
Hypoglycaemia is a very serious clinical sign of acute liver disease. How does it occur?
Liver is unable to mobilise glycogen stores, and gluconeogenesis is impaired
Fulminant hepatic failure is a division of acute liver failure - what happens in the former?
Encephalopathy and jaundice in previous normal liver
List some causes of fulminant hepatic failure
Wilson's, Budd Chiari (rare)
Is cirrhosis reversible?
Endstage of liver disease where bands of fibrosis separate hepatocytes
Chronic liver disease is defined as liver disease of duration > 6 months. True/False?
List some common causes of chronic liver disease
Primary biliary cirrhosis
What is NAFLD?
Non-alcoholic fatty liver disease
Caused by deposition of fat in the liver not attributed to alcohol intake
What are the 4 stages of NAFLD?
1. Steatosis (harmless fat build up)
2. Non-alcoholic steatohepatitis (NASH)
What is the most common cause of NAFLD?
How is simple steatosis diagnosed?
How is NASH diagnosed?
What is primary biliary cirrhosis?
Chronic liver disease where bile ducts in the liver become damaged, leading to build up of bile in the liver causing cirrhosis
Women get primary biliary cirrhosis more commonly than men. True/False?
How is primary biliary cirrhosis diagnosed?
What is the main treatment for primary biliary cirrhosis?