Flashcards in Pharmacology Deck (14)
Name a H2 receptor antagonist used to treat peptic ulcer disease
Name a proton pump inhibitor
Which drug may reduce the effects of long-term NSAID treatment?
Misoprostolol (PGE1 analogue)
What side effects can a NSAID have on the GI tract?
Why do NSAIDs cause gastric ulceration and bleeding?
Inhibit COX enzyme and thus block PGE formation - PGE reduces gastric acid secretions
What are the 3 main aims of drug treatment for peptic ulcers?
Decrease gastric secretions
Increase mucosal resistance
Eradicate H. pylori
What do proton pump inhibitors block?
The proton pump on the apical membrane (NOT the ones in tubulovesicles)
Name two mucosal strengtheners
Name 2 anti-emetic agents that are antagonists of the 5-HT3 receptor
Ondansetron (5-HT3 antagonist) is effective in reducing vomiting in chemotherapy patients, but has no effect on motion sickness. True/False?
Name a muscarinic ACh antagonist that can be used to treat motion sickness
Name a H1 antagonist that can be used to treat motion sickness + nausea/vomiting caused by irritants
Name a dopamine antagonist used for drug-induced and GI disease -induced vomiting