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Flashcards in Pharmacology Deck (14)
1

Name a H2 receptor antagonist used to treat peptic ulcer disease

Ranitidine

2

Name a proton pump inhibitor

Omeprazole

3

Which drug may reduce the effects of long-term NSAID treatment?

Misoprostolol (PGE1 analogue)

4

What side effects can a NSAID have on the GI tract?

Gastric bleeding
Mucosal ulceration

5

Why do NSAIDs cause gastric ulceration and bleeding?

Inhibit COX enzyme and thus block PGE formation - PGE reduces gastric acid secretions

6

What are the 3 main aims of drug treatment for peptic ulcers?

Decrease gastric secretions
Increase mucosal resistance
Eradicate H. pylori

7

What do proton pump inhibitors block?

The proton pump on the apical membrane (NOT the ones in tubulovesicles)

8

Name two mucosal strengtheners

Sucralfate
Bismuth chealate

9

Name 2 anti-emetic agents that are antagonists of the 5-HT3 receptor

Ondansetron
Palonosetron

10

Ondansetron (5-HT3 antagonist) is effective in reducing vomiting in chemotherapy patients, but has no effect on motion sickness. True/False?

True

11

Name a muscarinic ACh antagonist that can be used to treat motion sickness

Hyosine
Scopolamine

12

Name a H1 antagonist that can be used to treat motion sickness + nausea/vomiting caused by irritants

Cyclizine

13

Name a dopamine antagonist used for drug-induced and GI disease -induced vomiting

Metoclopramide

14

Name an NK1 antagonist used in conjunction with 5-HT3 antagonist in highly emetogenic chemotherapy

Aprepitant