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Flashcards in NSAIDs Deck (104)
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1

what are 4 uses of NSAIDs?

- Mild to moderate pain relief
- Anti-inflammatory
- Analgesic
- Anti-pyretic

2

What is the largest group of drugs having adverse effects?

NSAIDs

3

The use of lower doses of multiple drug classes provides higher safety and less negative side effects is known as what?

Multi-modal analgesia

4

NSAIDs have sparing effects on what other category of drug?

Opioids

5

What is the rate-limiting step of the arachidonic acid cascade?

Release of AA from membrane phospholipid catalyzed by enzyme phospholipase A2.

6

Cyclooxygenase (COX) oxidizes arachidonic acid (AA) to what?

Prostaglandins (PGs)

7

Lipoxygenase (LOX) oxidizes AA to what?

Leukotrienes

8

Are prostaglandins continually synthesized?

Yes

9

Are prostaglandins stored?

No

10

Where do prostaglandins act?

Locally at site of production.

11

T/F: Prostaglandins have only a few physiological functions.

False - Prostaglandins have many physiological functions.

12

What can inhibition of prostaglandins result in?

Serious side effects.

13

What are 2 functions of COX 1?

- Mucosal defense
- Platelet function (TxA2)

14

What effect does COX 2 have on mucosa?

Prevents erosions & promotes healing.

15

Which COX acts as an anti-inflammatory?
How?

- COX 2
- Inhibits leukocyte adherence

16

Which COX offers renal protection?

COX 2

17

Which COX is involved with fever initiation?

COX 3

18

What are 4 functions COX inhibition affects?

- Primary plug formation of platelets
- Renal & gastric mucosa vascular tone
- Smooth muscle contraction
- Temperature regulation

19

T/F: Different drugs inhibit COX 1, 2 & 3 variably.

True

20

Which COX is involved with vicero-nociception and thermal stimulation?

COX 1

21

T/F: COX 1 is involved in constitutive functions with COX 2.

True

22

Which COX is inducible?

COX 2

23

Which COX is up-regulated during inflammatory states?

COX 2

24

There is over a 20 times greater presence of which COX at injured sites?

COX 2

25

Which COX has a key role in nociception?

COX 2

26

What are 2 functions of COX 3?

- Pyrexia
- Analgesia

27

Does COX 3 have better or poorer anti-inflammatory properties than COX 1 & 2?

Poorer

28

COX 3 is derived from what?

COX 1 gene

29

What are 5 drugs that inhibit both COX 1 & 2?

- Aspirin
- Phenylbutazone
- Ketoprofen
- Ketorolac
- Flunixin meglumine

30

What are 5 drugs that are COX 2 preferential and have weak COX 1 inhibition?

- Meloxicam
- Carprofen
- Etodolac
- Vedaprofen
- Tolfenamic acid