Flashcards in NSAIDs Deck (104)
what are 4 uses of NSAIDs?
- Mild to moderate pain relief
What is the largest group of drugs having adverse effects?
The use of lower doses of multiple drug classes provides higher safety and less negative side effects is known as what?
NSAIDs have sparing effects on what other category of drug?
What is the rate-limiting step of the arachidonic acid cascade?
Release of AA from membrane phospholipid catalyzed by enzyme phospholipase A2.
Cyclooxygenase (COX) oxidizes arachidonic acid (AA) to what?
Lipoxygenase (LOX) oxidizes AA to what?
Are prostaglandins continually synthesized?
Are prostaglandins stored?
Where do prostaglandins act?
Locally at site of production.
T/F: Prostaglandins have only a few physiological functions.
False - Prostaglandins have many physiological functions.
What can inhibition of prostaglandins result in?
Serious side effects.
What are 2 functions of COX 1?
- Mucosal defense
- Platelet function (TxA2)
What effect does COX 2 have on mucosa?
Prevents erosions & promotes healing.
Which COX acts as an anti-inflammatory?
- COX 2
- Inhibits leukocyte adherence
Which COX offers renal protection?
Which COX is involved with fever initiation?
What are 4 functions COX inhibition affects?
- Primary plug formation of platelets
- Renal & gastric mucosa vascular tone
- Smooth muscle contraction
- Temperature regulation
T/F: Different drugs inhibit COX 1, 2 & 3 variably.
Which COX is involved with vicero-nociception and thermal stimulation?
T/F: COX 1 is involved in constitutive functions with COX 2.
Which COX is inducible?
Which COX is up-regulated during inflammatory states?
There is over a 20 times greater presence of which COX at injured sites?
Which COX has a key role in nociception?
What are 2 functions of COX 3?
Does COX 3 have better or poorer anti-inflammatory properties than COX 1 & 2?
COX 3 is derived from what?
COX 1 gene
What are 5 drugs that inhibit both COX 1 & 2?
- Flunixin meglumine