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Flashcards in Cervical Cancer Deck (127)
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1

What is cervical cancer?

Cancer arising from the cervix

2

What is the most common type of cervical cancer?

Squamous cell carcinoma

3

How does cervical cancer compare to other cancers in terms of prevalence worldwide?

3rd most commonly diagnosed world wide

4

How does cervical cancer compare to other cancers as causes of cancer deaths in women?

4th most common

5

How many new cases of cervical cancer are there each year in the UK?

3000

6

How many cervical cancer deaths are there each year in the UK?

850

7

How common is cervical cancer in women in the UK?

14th most common cancer in females

8

What % of cervical cancer cases in the UK are considered preventable?

99.8%

9

What is the most common age range for diagnosis of cervical cancer?

25-34 years old

10

What % of cervical cancers are squamous cell carcinomas?

70%

11

What are the other types of cervical cancer?

- Mixed pattern (15%)
- Adenocarcinoma (15%)

12

What stages of disease can all subtypes of cervical cancer causes?

Pre-invasive and invasive

13

How do most cases of cervical cancer progress to invasive disease?

From HPV infection to CIN to invasive disease

14

What does CIN stand for?

Cervical intraepithelial neoplasia

15

What is CIN?

A cytological diagnosis describing involvement of the epidermis

16

What are the subtypes of CIN?

CIN I-III

17

What is CIN I?

Disease confined to the lower 1/3 of the epithelium

18

What happens to most cases of CIN I?

They regress slowly (some progress)

19

What is CIN II?

Disease confined to the lower and middle thirds of the epithelium

20

What is CIN III?

Disease affecting the full thickness of the epithelium

21

What % of CIN III progress to invasive carcinoma within 2-10 years?

10%

22

What % of CIN III will regress spontaneously?

30%

23

How long does progression from CIN I to III take approximately?

7 years

24

What is invasive cervical cancer?

Where there is breach of the epithelial basement membrane at any point

25

What can invasive cervical cancer be divided into?

- Micro-invasive carcinoma
- Invasive carcinoma

26

What is micro-invasive carcinoma of the cervix?

Deepest invasive element is <5mm from the surface of the epithelium

27

What is invasive carcinoma of the cervix?

Deepest invasive element is >5mm from the surface of the epithelium or >7mm wide

28

What does invasive carcinoma of the cervix require in terms of assessment?

Formal staging

29

What is the most important risk factor for cervical cancer?

Presence of HPV infection

30

What % of cervical tumours have HPV infection involved?

99%