Flashcards in Cervical Cancer Deck (127)
What is cervical cancer?
Cancer arising from the cervix
What is the most common type of cervical cancer?
Squamous cell carcinoma
How does cervical cancer compare to other cancers in terms of prevalence worldwide?
3rd most commonly diagnosed world wide
How does cervical cancer compare to other cancers as causes of cancer deaths in women?
4th most common
How many new cases of cervical cancer are there each year in the UK?
How many cervical cancer deaths are there each year in the UK?
How common is cervical cancer in women in the UK?
14th most common cancer in females
What % of cervical cancer cases in the UK are considered preventable?
What is the most common age range for diagnosis of cervical cancer?
25-34 years old
What % of cervical cancers are squamous cell carcinomas?
What are the other types of cervical cancer?
- Mixed pattern (15%)
- Adenocarcinoma (15%)
What stages of disease can all subtypes of cervical cancer causes?
Pre-invasive and invasive
How do most cases of cervical cancer progress to invasive disease?
From HPV infection to CIN to invasive disease
What does CIN stand for?
Cervical intraepithelial neoplasia
What is CIN?
A cytological diagnosis describing involvement of the epidermis
What are the subtypes of CIN?
What is CIN I?
Disease confined to the lower 1/3 of the epithelium
What happens to most cases of CIN I?
They regress slowly (some progress)
What is CIN II?
Disease confined to the lower and middle thirds of the epithelium
What is CIN III?
Disease affecting the full thickness of the epithelium
What % of CIN III progress to invasive carcinoma within 2-10 years?
What % of CIN III will regress spontaneously?
How long does progression from CIN I to III take approximately?
What is invasive cervical cancer?
Where there is breach of the epithelial basement membrane at any point
What can invasive cervical cancer be divided into?
- Micro-invasive carcinoma
- Invasive carcinoma
What is micro-invasive carcinoma of the cervix?
Deepest invasive element is <5mm from the surface of the epithelium
What is invasive carcinoma of the cervix?
Deepest invasive element is >5mm from the surface of the epithelium or >7mm wide
What does invasive carcinoma of the cervix require in terms of assessment?
What is the most important risk factor for cervical cancer?
Presence of HPV infection