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Flashcards in Herpesviridae Deck (58)
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0

Which is not a property of Herpesviridae?
A)Capsid with helical symmetry
B)Enveloped
C)Double stranded DNA viruses
D)Only viruses assembled in the nucleus

A

Icosahedral dapat

1

Enumerate the members of Alphaherpesvirinae.Where does their latency happen?

HSV1,HSV2,VSV/HSV3
Neurons

2

Enumerate the members of Betaherpesvirinae. What is their common feature?

CMV, HHV6/HHV7
long periods of growth

3

Where does CMV produce latent infection?
A.glands
B.kidneys
C.neurons
D. A and B
E. B and C

D

4

Where do HHV6 & HHV7 produce latent infection?
A.glands
B.lymphoid tissue
C.neurons
D. A and B
E. B and C

B

5

Enumerate members of Gammaherpesvirinae. Where do they commence their latency?

Epstein-Barr Virus & Kaposi sarcoma- associated herpesvirus

Lymphoid tissue

6

False about Herpes Simplex Virus
A. HSV1 & HSV2 have same characteristics (50-70%)
B. They antigenically cross-react with VZV
C. They are zoonotic

C

Humans only: natural host

7

How is herpes simplex virus transmitted?

Spread by contact; virus is shed in saliva, tears, genital and other secretions

8

Is this an accurate initial pathogenesis of HSV?
spreads locally -->short-lived viraemia (spread in the bloodstream) occurs --> dissemination in the body

Yes

9

Where does latency of HSV exactly occur?

Craniospinal ganglia

10

Encephalitis, conjunctivitis, esophagitis, Herpes gladiatorum & Tracheobronchitis - in what HSV can these be found?
A. HSV1
B. HSV2
C. HSV3
D. All 3

A

11

Meningitis, perianal herpes may be found in
A. HSV1
B. HSV2
C. Both

B

12

Gingivostomatitis, tonsillitis, labialis, pharyngitis, genital herpes, Herpes whitlow may be found in
A. HSV1
B. HSV2
C. Both

C

13

• Most common manifestation of primary herpes infection

Acute Gingivostomatitis (‘singaw’)

14

Identify
• Recurrence of oral HSV
• A prodrome of tingling, warmth or itching at the site usually heralds the recurrence
• About 12 hours later, redness appears followed by papules and then vesicles

Herpes labialis/cold sore

15

Herpes simplex virus does not manifest in the:
A. eye
B. ear
C. genitals
D. brain

B

16

IV acyclovir is given in all cases
of suspected HSE before lab results are available.
True or False?

True

17

identify the HSV manifestation
arises from implantation of the virus
into the skin, typically affects the fingers

herpes whitlow

18

Which diagnostic method can distinguish between HSV and VSV?
A. Electron microscopy of vesicle fluid
B. Immunofluorescence of skin scrapings
C. Both
D. Neither

B

19

Method used used routinely for diagnosis of herpes simplex encephalitis
A. Electron microscopy of vesicle fluid
B. Immunofluorescence of skin scrapings
C. PCR
D. All 3

C

20

identify CPE of herpes virus

typical ballooning of cells

21

Acyclovir & Valacyclovir directly inhibit synthesis of __
A. DNA
B. RNA
C. Protein
D. Peplomers

A

22

recurrence of chickenpox is called __

Shingles

23

How does VZV enter the body? Where does it go after?

respiratory system then lymphoid tissue

24

Latency of VSV is in __

cerebral of posterior root ganglia

25

• Incubation period: 14-21 days
• self-limiting
• Fever, lymphadenopathy, widespread of vesicular rash

identify the VSV clinical manif

varicella

26

false about Shingles
A. Mainly affect a single dermatome of the skin
B. Any age but mostly in patients more than 50 year old
C. Latent virus reactivates in a motor ganglion and tracks
motor the sensory nerve to the appropriate segment
D. Characteristic eruption of vesicles in the dermatome;
often accompanied by intensive pain which may last for
months

C

sensory, not motor

27

In serology, presence of __ confirms past infection and immunity

VZV IgG

28

in serology, presence of __ confirms recent primary infection

IgM

29

What is used to prevent development of the illness in patients exposed to varicella?

ϒ-globulin of high varicella-zoster virus antibody titer