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Etiologic agent of syphilis

Treponema pallidum

1

Two ways of transmitting T.pallidum

Bet sexual partners
Fr mother to fetus

2

T.pallidum is
A.aerobic
B.microaerophilic
C.aerotolerant
D.facultative anaerobic

B

3

Which can be done to T.pallidum?
A.in vitro culture
B.light microscopy
C.dark field microscopy
D.all 3

C

Also: fluorescent antibody technique

4

True / False
Invasion of CNS can occur during any stage of syphilis

True

5

In primary syphilis, a lesion called ___ develops

Chancre

6

False abt chancre
A.painful and hard
B.no ulcer and inflammatory zone
C.incubation is 3 weeks
D.bilateral lymphadenopathy

A.

Painless ang chancre

7

In secondary syphilis, __ lesions are most common

Mucocutaneous

8

Characteristic penile and vaginal lesions that are similar to genital warts made by HPV

Identify

Condylomata lata

9

Serologic tests for syphilis may not be positive during early primary syphilis. T or F?

T

10

Serologic tests for syphilis are usually at their lowest titer during secondary syphilis. T or F?

F

Highest dapat

11

In latent syphilis, the only evidence is the __

Positive serologic test for syphilis

12

What is the common clinical manifestation between early neurosyphilis and late neurosyphilis?

Ocular involvement

13

Identify: central necrosis, deep ulcer with a gummy base

gumma

14

T or F: Congenital syphilis may occur only during tertiary syhilis.

False
Any stage dapat

15

Which is not a direct manifestation of congenital syphilis?
A. mucous patches
B. Hutchinson's teeth
C. cerebral palsy
D. perforation of palate

C

16

Which is false?
A. Treponemal tests are qualitative.
B. Nontreponemal tests are both qualitative and quantitative.
C. The use of one quantitative test is enough for diagnosis
D. Both types of serological test may be reactive for life

C

one is not enough

17

Which method measures antibody directed T.pallidum antigens?
A. treponemal
B. nontreponemal
C. both A and B
D. neither A nor B

A

18

Which method measures antibodies directed against a cardiolipin-lecithin cholesterol antigen?
A. treponemal
B. nontreponemal
C. both A and B
D. neither A nor B

B

19

T or F
In nontreponemal tests, only false positive tests may occur.

F

prozone effect may also cause false negative tests.

20

In diagnosing latent syphilis, which is not a criteria?
A. 3-fold increase compared to serologic titer obtained within the year preceding the evaluation
B. seroconversion
C. contact to infectious syphilis case
D. none of the above

A

4-fold dapat

21

T or F: Neurosyphilis may occur at any stage of syphilis

T

22

What is the standard serological test for CSF?

VDRL-CSF

23

False about Neurosyphilis diagnosis
A. CSF leukocyte count is usually high in people with neurosyphilis
B. When VRDL-CSF is reactive in the absence of contamination of the CSF with blood, the patient has neurosyphilis.
C. If VRDL-CSF is positive but there are no clinical manifestations, the patient is likely to not have neurosyphilis.
D. All are true.

C
positive VRDL-CSF --> neurosyphilis, with or without clinical manifestations.

24

___ is the drug of choice for primary, secondary, early latent and late latent syphilis

Benzathine Penicillin G

25

___ is the drug of choce for neurosyphilis

Aqueous crystalline penicillin G

26

What is Jarrisch-Herxheimer reaction?

self-limited reaction to anti-treponemal therapy

27

T or F: Jarrisch-Herxheimer reaction is caused by an allergic reaction to penicillin

F

28

Causative agent of YAWS

Treponema pallidum subspecies Pertenue

29

In early yaws, a primary papule/group of papules appear at the site of inoculation after 3 weeks of incubation. This usually becomes large and crusted. this is called:

Mother Yaw/Maman pian