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Flashcards in Rabies Deck (59)
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1

family of rabies virus

Rhabdoviridae

2

genus of rabies virus

Lyssavirus

3

false about rabies virus
A.75 nm to 180 nm, bullet shaped
B.May only be seen via electron microscope
C.Single-stranded, negative-sense DNA virus

C

RNA, not DNA

4

Enumerate main parts of the rabies virus structure

envelope, peplomers, ribonucleocapsid

5

false about rabies virus
A.Survives storage at 4 ̊C for weeks and -70 ̊C for years B.Activated by carbon dioxide, extremes of pH, detergent
C.Inactivated by UV radiation,sunlight, trypsin, heat, lipid solvent

B

inactivated dapat

6

false about rabies virus
A.Has two serotypes
B.Purified spikes with viral glycoprotein elicit neutralizing
antibody in animals
C.Antiserum prepared against the purified nucleocapsid is
used in diagnostic immunofluorescence for rabies

A

one serotype only

7

Strain differences can be distinguished by three factors. Enumerate the three factors.

Epitopes in nucleoprotein
specific nucleotide sequences
glycoprotein

8

What mutation results in loss of virulence for the rabies virus?

substitution at amino acid position 333

9

What mediates attachment of rabies virus to host cell?

glycoprotein spikes

10

host cell receptor of rabies virus (attachment)

nicotinic acetylcholine

11

enzyme in-charge of transcription for rabies virus

virion-assoc RNA polymerase

12

transcription template for rabies virus

ribonucleoprotein

13

product of transcription, rabies virus

5 mRNA species

14

enumerate the three substances involved in RNP Core Formation

viral transcriptase
nucleoprotein
newly rep viral RNA

15

true about outer covering formation of rabies virus
A.Envelope gained via budding through plasma membrane
B.Viral matrix protein forms a layer on the outer side of the envelope
C.Viral glycoprotein – inner layer, c/o spike formation

A

Baliktad ang B at C. switch the words inner and outer!

16

False about viral RNA Replication for rabies
A. complementary negative sense RNA formed from genome RNP
B. the (-)sense RNA is used to code for negative-sense progeny RNA
C. both are false
D. both are true

C

change negative to positive

17

incubation period for Rabies

2 weeks to 6 months

18

In pathogenesis of rabies, which does not happen?
A. it goes straight to CNS
B. multiplication in skin
C. entry into peripheral
nerves at neuromuscular junctions
D. travels at axoplasm, rate is 10 mm/hr

B

Muscle or connective tissue dapat

19

Once rabies has entered the CNS, what occurs?

progressive encephalitis

20

__ is the organ with highest titers
of virus

Submaxillary salivary gland:

21

A brain infected with rabies is not/does not have:
A.edematous
B.perivascular cuffing
C.gliosis with maximal neuronal damage

C

minimal dapat

22

Specific eosinophilic cytoplasmic inclusions formed by rabies virus in nerve cells
o Filled with viral neurocapsids
o Absent in at least 20%(may reach until 50%) of cases

identify

Negri bodies

23

#1 rabies infected country

India

24

Which is not a usual reservoir host of rabies?
A. dogs
B. zebras
C. vampire bats
D. raccoons

B

25

Which is not a frequent mode of transmission of rabies?
A. Contact with saliva, milk or urine of animal suffering from rabies
B. Licks on wounds
C. Scratches/bites of animals
D. Aerosol

D

26

Which is false?
A. Rabies has no cure.
B. Rabies has no vaccine.
C. The saliva is infective 2-3 days before signs of rabies manifest in the infective animal.

b

27

enumerate two types of rabies

furious rabies
paralytic rabies

28

first phase of furious rabies, Tingling and numbness at the site of bite 2-3 days
before clinical symptoms appear

prodromal phase

29

Which does not happen in a person with furious rabies?
A.Low grade fever, headache, body ache
B.Painful spasms of the muscles that control
breathing and swallowing
C. Pupils are dilated
D. Tears, blood pressure and perspiration increase

D

blood pressure decreases

30

T or F
Furious and paralytic rabies have the same prodromal phase

T