Flashcards in HIV/AIDS Deck (54)
genus of HIV
criterion for differentiation @ HIV types: enumerate
(1) genetic make-up
(2) geographic distribution
majority of cases; pandemic, from sub-Saharan Africa
HIV-1 has subtypes M, N and O. Which causes global epidemics?
HIV-1 subtype Localized to Cameroon, Gabon &
HIV-1 subtype in Cameroon only
subtype E of HIV-1 is now classified as __
CRF (circulating recombinant form)
Why is HIV capable of producing circulating recombinant form?
Because its segmented linear genome is prone to mutation
(1) No cases in the Philippines
(2) No HIV-2 pandemic
(3) Less pathogenic than HIV-1
Which is false about HIV-2?
we have 1 case; however it is more seen in West Africa
What is the genome of HIV?
A pair of (+) ssRNA
shape of capsid containing RNA
T or F: HIV is a naked virus.
F. It has an envelope
In the viral envelope of HIV-1, the peplomer cap is also known as __
In the viral envelope of HIV-1, the peplomer stalk is also known as __
gp120 and gp41 come from __
enumerate the 3 major genes of HIV
Group Specific Antigen
codes for capsid protein, matrix protein, nucleocapsid
Group Specific Antigen
codes for reverse transcriptase, protease, integrase,
and ribonuclease; unique for HIV
encode for (1) surface protein, (2) transmembrane
identify the accessory gene: essential for replication specifically for elongation
TAT gene (transcriptional activator)
identify the accessory gene: bringing mRNA into translations
REV gene (regulator of viral gene expression)
enumerate the 2 main differences of HIV-1 & HIV-2
(2) weight of each of the component of the virion
HIV-2 __ HIV-1 (weight)
envelope precursor of HIV-2
HIV binds to CD4 antigen on cells such as Macrophages
and T-Helper cells via the ___
HIV surface glycoprotein, gp120
Once HIV has attached & chemokines stabilize the interaction, __ changes --> exposing hydrophobic
regions that embed in the membrane of host cell.
Which co-receptor isn't one of those which HIV has to attach to?
C. CR5 & CXCR4
another name for CXCR4
Which is false about HIV?
a. There is fusion between the membranes of the virus and the host cell before entry of nucleocapsid.
b. Initial infection of HIV is abundant in the mucosa.
c. There is formation of syncytia with the isolation of
the virus in cell lines.