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Flashcards in HIV/AIDS Deck (54)
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1

genus of HIV

Lentivirus

2

criterion for differentiation @ HIV types: enumerate

(1) genetic make-up
(2) geographic distribution

3

majority of cases; pandemic, from sub-Saharan Africa
A. HIV-1
B. HIV-2
C. HIV-3

A

4

HIV-1 has subtypes M, N and O. Which causes global epidemics?

M (majority)

5

HIV-1 subtype Localized to Cameroon, Gabon &
Equatorial Guines

O

6

HIV-1 subtype in Cameroon only

N

7

subtype E of HIV-1 is now classified as __

CRF (circulating recombinant form)

8

Why is HIV capable of producing circulating recombinant form?

Because its segmented linear genome is prone to mutation

9

(1) No cases in the Philippines
(2) No HIV-2 pandemic
(3) Less pathogenic than HIV-1

Which is false about HIV-2?

(1)

we have 1 case; however it is more seen in West Africa

10

What is the genome of HIV?

A pair of (+) ssRNA

11

shape of capsid containing RNA

Conical

12

T or F: HIV is a naked virus.

F. It has an envelope

13

In the viral envelope of HIV-1, the peplomer cap is also known as __

gp120

14

In the viral envelope of HIV-1, the peplomer stalk is also known as __

gp41

15

gp120 and gp41 come from __

gp160

16

enumerate the 3 major genes of HIV

Envelope
Polymerase
Group Specific Antigen

17

codes for capsid protein, matrix protein, nucleocapsid

Group Specific Antigen

18

codes for reverse transcriptase, protease, integrase,
and ribonuclease; unique for HIV

Polymerase

19

encode for (1) surface protein, (2) transmembrane
protein

Envelope

20

identify the accessory gene: essential for replication specifically for elongation

TAT gene (transcriptional activator)

21

identify the accessory gene: bringing mRNA into translations

REV gene (regulator of viral gene expression)

22

enumerate the 2 main differences of HIV-1 & HIV-2

(1) structure
(2) weight of each of the component of the virion

23

HIV-2 __ HIV-1 (weight)
A. >
B. <
C. =

A

24

envelope precursor of HIV-2

gp140

25

HIV binds to CD4 antigen on cells such as Macrophages
and T-Helper cells via the ___

HIV surface glycoprotein, gp120

26

Once HIV has attached & chemokines stabilize the interaction, __ changes --> exposing hydrophobic
regions that embed in the membrane of host cell.

gp41

27

Which co-receptor isn't one of those which HIV has to attach to?
A. CKR5
B. CCR5
C. CR5 & CXCR4
D. R4

C

R5 dapat

28

another name for CXCR4

fusin

29

Which is false about HIV?
a. There is fusion between the membranes of the virus and the host cell before entry of nucleocapsid.
b. Initial infection of HIV is abundant in the mucosa.
c. There is formation of syncytia with the isolation of
the virus in cell lines.

C

No syncytia

30

Initial infection of HIV is __
A. T-tropic
B. M-tropic
C. Both

B