Allergy Flashcards Preview

Year 3: CSP & PH > Allergy > Flashcards

Flashcards in Allergy Deck (8):
1

What are mast cells stimulated by?

• Surface IgE binding antigen.
• Complement activation: C5a, C3a.
• Nerves: axon reflex sensory nerves, Substance P.
• Direct stimulation.

2

What substance is raised in anaphylaxis?

Tryptase (and D dimers)

3

What are anaphylactoid reactions?

Direct/indirect activation of mast cells without IgE

4

What are the common causes of anaphylactoid reactions?

o Drugs – opiates, vancomycin, anaesthetics, NSAIDs
o Foods: strawberries

5

What is hereditary angioedema?

Episodes of severe swelling of the subcutaneous tissues, associated with deficiency of C1 esterase inhibitor (type 1 and 2) or mutation of factor XII gene (type 3)

6

What is the treatment of angioedema?

Anabolic steroids or tranexamic acid

7

What might cause acquired C1 esterase inhibitor deficiency?

Autoimmune disease, Hep B/C, helicobacter --> angioedema

8

Define 'atopy'

The genetic predisposition to make IgE antibody against common environmental antigens. Associated with hayfever, childhood asthma and atopic dermatitis