The Allergic Lung Flashcards Preview

Year 3: CSP & PH > The Allergic Lung > Flashcards

Flashcards in The Allergic Lung Deck (5)

What causes the switch in B cells from IgM to IgE?

• First signal is by IL-4 or IL-13
The second signal is when CD14 on B cells binds to its ligand on T cells


What are the clinical features of bronchial asthma?

• Acute attacks of SOB due to contraction of smooth muscle
• Mucus hypersecretion
• Airway inflammation
• Bronchial hyper-responsiveness


Which cytokine prolongs the survival of eosinophils?



Outline the phases of asthma

• Bronchospasm – lasts 2 hours past exposure to trigger
• Inflammation – occurs about 4 hours after a trigger and lasts for about 3 hours


What cytokines regulate eosinophils?

IL-3, IL-5