Therapeutic Drug Monitoring Flashcards Preview

Year 3: CSP & PH > Therapeutic Drug Monitoring > Flashcards

Flashcards in Therapeutic Drug Monitoring Deck (8):
1

What is meant by first order kinetics?

Rate of elimination is proportional to the amount of drug

2

What is meant by zero order kinetics?

Rate of elimination is independent of the amount of the drug (ethanol, phenytoin, salicyclates)

3

Give examples of drugs with a wide therapeutic index

NSAIDs, benzodiazepines, antibiotics, beta blockers

4

Give examples of drugs with a narrow therapeutic index

Anti-epileptics (phenytoin, sodium valproate), lithium, strong antibiotics (gentamycin, amikacin, vancomycin), digoxin, immunosuppressives (ciclosporin, tacrolimus)

5

What drug levels are commonly monitored during their use?

Digoxin, aminophylline, phenytoin, carbazmazepine, lithium, gentamycin, amikacin, vancomycin, ciclosporin

6

What are digoxin levels affected by?

Renal impairment, amiodarone and hypokalaemia

7

When should you check genatmycin levels?

o If they are taking once daily – check level dose after 3 doses
o If they have renal impairment – check their trough level
o For multiple daily dosing (as in infective endocarditis) – do a peak level after the 3rd dose and a trough level before the next dose

8

When should you check digoxin levels?

6 hours after previous dose