Therapeutic Drug Monitoring Flashcards Preview

Year 3: CSP & PH > Therapeutic Drug Monitoring > Flashcards

Flashcards in Therapeutic Drug Monitoring Deck (8)

What is meant by first order kinetics?

Rate of elimination is proportional to the amount of drug


What is meant by zero order kinetics?

Rate of elimination is independent of the amount of the drug (ethanol, phenytoin, salicyclates)


Give examples of drugs with a wide therapeutic index

NSAIDs, benzodiazepines, antibiotics, beta blockers


Give examples of drugs with a narrow therapeutic index

Anti-epileptics (phenytoin, sodium valproate), lithium, strong antibiotics (gentamycin, amikacin, vancomycin), digoxin, immunosuppressives (ciclosporin, tacrolimus)


What drug levels are commonly monitored during their use?

Digoxin, aminophylline, phenytoin, carbazmazepine, lithium, gentamycin, amikacin, vancomycin, ciclosporin


What are digoxin levels affected by?

Renal impairment, amiodarone and hypokalaemia


When should you check genatmycin levels?

o If they are taking once daily – check level dose after 3 doses
o If they have renal impairment – check their trough level
o For multiple daily dosing (as in infective endocarditis) – do a peak level after the 3rd dose and a trough level before the next dose


When should you check digoxin levels?

6 hours after previous dose