Prescribing by different routes Flashcards Preview

Year 3: CSP & PH > Prescribing by different routes > Flashcards

Flashcards in Prescribing by different routes Deck (16):
1

When deciding how to administer a drug, what factors should you consider?

Bioavailability, desired peak-trough levels, release time, availability/tolerability of route, contraindications and risks.

2

When would you consider using IV administration of a drug?

100% bioavailability; better to be given in circumstances where regular, smaller doses can be administered, such as in a hospital setting

3

How much liquid can you give via subcutaneous injection per day?

48ml/24hr

4

Which mode of administration is contraindicated in haemophilia?

Intramuscular injection

5

When might you consider administering a drug via an intramuscular route?

entry of small volume with fast entry into the systemic circulation

6

Why may hyaluronidase be used alongside an intramuscular injection?

Allows breakdown of the ECM to increase the rate of diffusion (uptake)

7

What is meant by 'intrathecal' adminstration?

Injection into the dura mater around the spinal cord

8

When may you administer a drug intrathecally?

Injection into the dura mater around the spinal cord may be used for single-dose analgesia e.g. Baclofen for spasiticity

9

What complication may occur with intrathecal drug administration?

Respiratory depression

10

What is meant by an 'epidural'?

Where an injection of a drug is given just above the dura mater of the spinal cord

11

Why may you choose to administer a drug epidurals rather than intrathecally?

Epidural - a large volume can be administered by this method by comparison, and there is the potential to insert an in-dwelling catheter to allow for drug top-up

12

Describe the intranasal route of drug adminstration

Nasal mucosa is highly vascularised; so decongestants can be used in this way, but also systemic drugs e.g. desmopressin etc.

13

When might you consider giving a medication per rectally?

Vomiting/nausea/NBM or IV access is difficult to obtain (e.g. status epilepticus)

14

When may you consider giving a drug buccally or sublingually?

If a drug is unstable at gastric pH or are rapidly metabolised by the liver; oral mucosa facilitates very quick absorption

15

When might you use intraosseous drug administration?

Cardiopulmonary arrest or paediatric resuscitation --> drugs administered into the medullary cavity of the long bones (usually tibia or fibula)

16

What are the potential complications of intraosseous drug adminstration?

Embolism, compartment syndrome, fractures, osteomyelitis