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Flashcards in Biochemistry nutrition Deck (21)
1

Fat soluble vitamins

A D E K

2

Name the following vitamins
B1
B2
B3
B5
B6
B7
B9
B12
C

1 Thiamine
2 Riboflavin
3 Niacin
5 Pantathenic acid
5 Pyridoxine
7 Biotin
9 Folate
12 Cobalamin
C Ascorbic acid

3

Vitamin A deficiency

Night blindness
Scaly dry skin and bitot conjunctiva spots.

4

Vitamin B1 deficiency

thiamine deficieny
Strongly related to the TCA cycle
LEads to wernicke korsakof syndrome
Dry beriberi
Wet beri beri

Due to impaired lucose breakdown/ATP depletion.

5

Wernicke korsakoff syndrome

confusion, opthalmoplegia, and ataxia are the classic triad.

thiamine deficiency/B1

6

Dry Beri Bery

Secondary to thiamine deficiency (B1)
Polyneuritis, symmetrical muscle wasting.

7

Wet Beri Beri

High output cardiac failure (dilated cardiomyopathy), edema.

Secondary to thiamine (B1) deficiency.

8

Vitamin B2 (riboflavin) deficiency

FAD and FMN cofactor deficiency.
Leads to cheilosis (inflammation of lips, scaling and fissures at corners of the mouth)
and corneal vascularization.

"The 2 C's of B2"

9

Vitamin B3 deficiency

Niacin deficiencyies result in lack of NAD and NADP+ formation. Derived from tryptophan. Synthesis requires B2 and B6.

Deficiency results in glossitis, pellagra.

10

Pellagra

Niacin B3 deficiency
Diarrhea
dementia
Dermatitis -> Broad collar rash

11

Vitamin B5 deficiency

Essential for Co-enzyme A and fatty acid synthesis
Dermatitis, enteritis, alopecia, and adrenal deficiency occurs.

12

Vitamin B6 (pyridoxine) deficiency

Used for the creation of many catecholamines.
Leads to convulsions, hyperirritibility, peripheral neurppathy and sideroblastic anemias.

13

B7 (biotin deficiency)

Cofactor for the carboxylation enzymes

deficiencies are rare, but leads to dermatitis, alopecia, enteritis.

14

Vitamin B9 Folate deficiency

Converted to THF important for DNA and RNA formation.

Leads to macrocytic and megaloblastic anemia. Homocysteine levels will be high in lab results.

15

Vitamin B12 deficiency

Macrocytic, megaloblastic anemia
Hypersegmented PMNs
formed through animal products and stored in the liver.

requires intrinsic factor to pick up from the intestine.

16

Vitamin C deficiency

Scurvy - Collagen synthesis deficiency

note also that calcium is important for iron absorption and the conversion of dopamine to norepinephrine.

17

Vitamin D deficiency

Rickets in children
Osteomalacia in adults
Excessive PTH release to make up for lack of calcium absorption.

18

Vitamin E deficiency

Usually an antioxidant that protects RBC so a deficiency results in hemolytic anemia

19

Vitamin K deficiency

Important for clotting factors.
Thus lack results in neonatal hemorrhage with an increased PT and PTT

20

What is kwashiokor malnutrition?

Protein malnutrition resulting in skin lesions and edema due to decreased oncotic pressure with liver malfunction.

21

What is marasmus malnutrition?

Total calorie malnutrition resulting in tissue and muscle wasting*, loss of subcutaneous fat, and variable edema.

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