Pathology - Neoplasia Flashcards Preview

A - Board Reveiew Misc > Pathology - Neoplasia > Flashcards

Flashcards in Pathology - Neoplasia Deck (19)
1

Neoplasia

New tissue growth unregulated, irreversible, and monoclonal.

2

Oncogenes

Proto oncogenes essential for cell growth and differentiation.

3

ERBB2 (HER2)

Epiderma growth factor receptor related to breast cancer.

4

RET

Neural growth factor receptor.

5

ABL-tyrosine kinase

CML, some types of ALL

6

c-MYC

transcription factor
Seen in burkitts lymphoma.

7

n-MYC

Transcription factor
Neuroblastoma

8

L-MYC

TF
Small cell lung cancer

9

CCND1

Cyclin related in mantle cell lymphoma

10

CDK4

Melanoma related CDK.

11

P53

Regulates progression from the G1 to S phase.

DNA damage slows the cell cycle for DNA repair.

12

RB protein

regulates progression from G1-S phase
Holds E2F for transition.

13

What happens if the RB protein is knocked out?

Unilateral retinoblastoma (Sporadic mutation) and familial retinoblastoma (germline mutation)

14

Bcl-2

Blocks the release of cytochrome c from the mitochondria preventing apoptosis.

disruption leads to apoptosis.

15

Follicular lymphoma

Overexpressive the Bcl-2 stabilizing cells from releasing cytochrome c and apoptosis.

16

How do tumor clls evade the host immunity?

They downregulate MHC-1

17

Most common metastasis to liver

Colon, stomach, pancrease

18

Most common metastasis to brain

Lung, breast, prostate, melanoma

19

Most common metatasis to the liver

Colon, stomach, pancrease.

Decks in A - Board Reveiew Misc Class (64):