Flashcards in Pathology - Neoplasia Deck (19)
New tissue growth unregulated, irreversible, and monoclonal.
Proto oncogenes essential for cell growth and differentiation.
Epiderma growth factor receptor related to breast cancer.
Neural growth factor receptor.
CML, some types of ALL
Seen in burkitts lymphoma.
Small cell lung cancer
Cyclin related in mantle cell lymphoma
Melanoma related CDK.
Regulates progression from the G1 to S phase.
DNA damage slows the cell cycle for DNA repair.
regulates progression from G1-S phase
Holds E2F for transition.
What happens if the RB protein is knocked out?
Unilateral retinoblastoma (Sporadic mutation) and familial retinoblastoma (germline mutation)
Blocks the release of cytochrome c from the mitochondria preventing apoptosis.
disruption leads to apoptosis.
Overexpressive the Bcl-2 stabilizing cells from releasing cytochrome c and apoptosis.
How do tumor clls evade the host immunity?
They downregulate MHC-1
Most common metastasis to liver
Colon, stomach, pancrease
Most common metastasis to brain
Lung, breast, prostate, melanoma