Pathology - Musculoskeletal Flashcards Preview

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Flashcards in Pathology - Musculoskeletal Deck (27)
1

Blue sclera, hearing loss, multiple fractures

Osteogenesis imperfecta

Defect in bone resorption --> Weak bone and type 1 collagen defect.

2

Osteopetrosis

Abnormally thick and heavy bone due to defective osteoclasts.

3

Rickets

Vitamin D deficiency in children

4

Osteomalacea

Vitamin D deficiency in adults

5

Osteoporosis

Reduction in TRABECULAR BONE MASS!

Check with DEXA scan

6

Pagets disease

Osteoblast/Osteoclast imbalance.

Localized process/.

7

Osteomyelitis

Infection of the bone marrow

Lytic focus with sclerotic rings on X-rays.

8

Osteotoma

Benign tumor of bones

Most commonly in the facial bone.

9

Osteoid osteoma

Benign tumor of osteoblasts surrounded by a rim of reactive bone.

Most common in the cortex of long bones in young adults. Pain settles with aspirin.

will have osteoid radiolucent core.

10

Bone tumor with pain that wont resolve with aspirin.

Osteoblastoma.

11

Tumor of bone with an overlying cartilage cap.

Osteochondroma.

12

Tumor comprised of multinucleated giant cells and stromal cells found in the epiphysis

Giant cell tumor

13

Soap bubble bone lesion

Giant cell tumor

14

Poorly differentiated cells derived from neuroectoderm.

Seen in the diaphysis of male children.

Eqing sarcoma.

15

Onion skin appearance on X-ray of bone tumor.

Ewings sarcoma.

16

Tumor of cartilage seen in the medulla of small bones in the hands and feet.

Chondroma.

17

Malignant cartilage forming tumor

Chondrosarcoma.

18

Osteolytic punched out lesions!

Metastic tumors to the bone!

"People Like To Break Bones"

Prostate Lung Thyroid and Breast

19

Herberden nodes vs Bouchard nodes

DIPJ - Herberden

PIPJ - Bouchard

These are seen in osteoarthritis.

20

IgM auto antibody agaisnt the Fc portion of IgG in the presence of pannus

Rheumatoid arthritis.

21

HLA b27 involvement with no rheumatoid factor

Ankylosing sponyloarhtritis.

22

Lower back pain with bamboo spine and possible aortig regurg

Ankylosing spondylarthritis.

23

Inflammation of the skin and skeletal muscle showing rashes on upper eyelids and papules on joints.

Dermatomyositis.
Look for high CK and positive ANA/ anti-Jo 1 -Ab

24

Inflammatory disorder of the skeletal muscle NOT INVOLVING A SKIN RASH

Polymyositis

Looks alot like dermatomyositis but with no skin involvement.

25

Auto-Ab against the postsynapitc ACh receptor at the NMJ

Myasthenia gravis.

Muscle weakness gets worse with rest.

26

Antibodies against the presynaptic calcium channels at the NMJ.

Lambert Eaton

Weakness will get better with use.

27

Rhabdomyoma

Benign tumor of skeletal muscle

cardiac rhabdomyoma is associated with tuberous sclerosis.

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