Flashcards in Hematology Phys Deck (24)
Bite Cell AKA degmacyte
and Hypersegmented PMN's
Will also present with hypersegmented PMN's
Sideroblastic anemia which is excessive iron in mitochondria.
What would it mean if you see a tear drop cell?
Dacrocytes are caused by bone marrow infiltration
"Mechanically squeezed out of bone marrow"
When would you see Target RBCs?
When would you find heinz bodies?
Oxidation of the Hb-Sh groups with bite cells most commonly seen in G6PD deficency and alpha thalasemia. `
When would you see Howel-Jolly bodies?
Basophillic nuclear remnants normally removed by macrophages in the spleen.
Thus seen in pt with functional hyposplenia or asplenia.
What s the normal range of size for RBC?
Think like a score of 80-100 is an okay score.
What is plummer Vinson syndrome?
Seen in iron deficiency.
How will lead poisoning manifest?
Inhibits ferrochelatase and ALA dehydratase.
Decreases heme synthesis and RBC protoporphyrin.
Basophlic stippling wil be seen as well.
Think of an old house, children and chipped paint!!!
What are the antidotes of lead poisoning?
EDTA and Dimercaprol
EDTA can be used in children.
What vitamin deficiency most commonly leads to sideroblastic anemia?
Treat with pyridoxone.
What are the most common disorders that lead to microcytic anemias?
B6 deficiency --> Sideroblastic anemia.
What two factors can lead to megaloblastic anemia?
B12 and Folate deficiency
With folate deficiency there will be no neurologic symptoms!!!
With B12 there will be.
Describe bernard soulier syndrome
Defect in GpIb and its binding to Von Willebrand Factor.
Describe Glanzmann thrombasthenia
Defect in GpIIb/IIIa and platelet to platelet aggregation.
Antibodies directed againt the Gpb/IIa complex. `
Thrombotic thrombocytopenic purupura
Increase in vWF multimers.
why is PTT increased with lack of VWF?
Because vWF carries factor 8!
What is factor V leiden disease?
hypercoaguability along with factor V that is resistant to Protein C degredation.
Will show subcutaneous tissue necrosis after warfarin administration.
When would you use fresh frozen plasma?
DIC, cirrhosis, immediate warfarin reversal.