Flashcards in Pathology - General disorders Deck (11)
Developmental failure of the 3/4th pharyngeal pouches due to a 22a11 microdeletion
Will lack the thymus.
Defective cell mediated and humoral deficiency due to cytokine receptor defects and lack of maturation of B and T cells.
Severe combine immuno deficiency (SCID)
Complete lack of immunoglobulin.
typically seen with recurrent infections after 6 months of life.
Low serum IgA very common.
Increased risk of mucosal infections.
Mutation of WASP gene X-linked leading to thrombocytopenia, eczema, and recurrent infections.
Wiskott Aldrich Syndrome
What is one who is deficient in C5-C9 at greater risk of?
What type of hypersensitivities are seen in SLE?
Type II Cytotoxic and Type III Complement
What disorder has a classic finding of small sterile deposits on both sides of the mitral valve known as libman Sacks endocarditis?
Look for antinuclear antibody and anti-dsDNA antibody.
Antihistone Ab is related to SLE in which way?
Highly indicative of drug induced lupus.
think hydralazine, procainamide and isoniazid.
destruction of lacrimal and salivary glands.
Characterized by ANA and anti-ribonucleotide antibodies.