Renal pathology First Aid Flashcards Preview

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Flashcards in Renal pathology First Aid Deck (20)
1

Distal Type 1 renal tubular acidosis

Defect in the alpha intercalated cells to secrete H+
No new HCO3- is formed so leads to acidosis.

Associated with hypokalemia
AMPHOTERICIN B TOXICITY

2

Type II Renal tubular acidosis

Defect in PCT HCO3- reabsorption leads to mtabolic acidosis.

Associated with hypokalemia

Think of carbonic anhydrase inhibitors (acetezolamide)

3

Type IV renal tubular acidosis

Hypoaldosteronism leading to hyperkalemia and decreased NH4 excretion.

Seen with diabetic hyporeninism, ACE inhibitors, ARBs, NSAIDs, Heparin, cyclosporine, adrenal insufficiency or aldosterone resistance TMP/SMX

4

RBC casts in urin

Glomerulonephritis, malignant hypertension

5

WBC casts in urine

Tubulointerstitial inflammation, acute pyelonephritis, transplant rejection.

6

Fatty Casts in urine

Nephrotic syndrome!!

7

Granular/ muddy brown casts in urine

Acute tubular necrosis!!!!

8

What is nephritic syndrome?

Decay of the glomerular basement membrane leadin to blood leaking out. Not much protein leaked out.

9

what is nephrotic syndrome?

Podocyte disruption leading to loss of the negatively charged barrier.

Results in massive proteinuria and hypoalbuminemia.

10

What is nephritic-nephrotic syndrome?

Severe nephritic syndrome with profound glomerular basement membrane damage leading to protein increase and blood increase.

11

Nephritic disorder in which there are cresencts of fibrin and plasma proteins with glomerular pariertal cells present

Rapidly progressive crescentic glomerulonephritis

Very related to goodpasture syndrome (type II hypersensitivity)

12

A type of nephritic syndrome due to SLE showing wire looping of capillaries.

Diffuse proliferative glomerulonephritis.

13

Mesangial proliferation seen with IgA based IC deposits in the mesangium.
Which nephritic syndrome does this present with?

IgA nephropathy.
Also known as Berger Disease/ Henoch schonlein purpura

14

Mutation in type IV collagen thining the glomerular basement membrane resulting in nephritic syndrome.

Alport syndrome

15

Tram track nephritic syndrome?

Membrano proliferative glomerulonephritis.

Type II may be related to hepatitis B or C infections.

Type II associated with C3 nephritic factor.

16

What should nephrotic syndrome tip you off to?

Should tip you off to nephrotic syndrome, passing of protein.

Specifically due to podocyte damage.

17

Kimmelstiel wilson lesions

Diabetic glomerulonephropathy

18

What kidney stone is related to proteus mirabilis, staph saprophyticus, and klebsiella?

Ammonium magnesium phosphate

Will have coffin lid like crystal.

19

Hexagonal like crystals

Cystine crystals that are hereditary with six sides.

20

what is hydronephrosis?

Distention/dilation of the renal pelvis and calyces

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