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Flashcards in MDD and bipolar II Deck (54)
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1

What is the role of psychotherapy and psychopharmacology?

Complementary--psychopharmacology outcomes are largely improved with psychotherapy

2

What is transcranial magnetic stimulation?

A noninvasive method used to stimulate small regions of the brain. During a TMS procedure, a magnetic field generator, or "coil", is placed near the head of the person receiving the treatment. The coil produces small electric currents in the region of the brain just under the coil via electromagnetic induction. The coil is connected to a pulse generator, or stimulator, that delivers electric current to the coil

3

What is the role of ketamine in the treatment for depression? What is the MOA?

Rapid response

NMDA receptor antagonist

4

What is the role of exercise in MDD?

Treatment, but not cure

5

What is the black box warning for antidepressants?

Increase risk for suicidal ideation if young. Usually occurs in the first 2 weeks

6

True or false: improvements in mood can be seen in the first week of antidepressant therapy

True, but smaller than full effect

7

What is the MOA of duloxetine?

SNRI

8

What is the difference in response vs remission in the treatment of MDD?

-Response = 50% reduction
-Remission = 100%

9

Should you dose antidepressants according to severity of symptoms?

No

10

What are the major TCAs?

Imipramine
Amitriptyline

11

What is the MOA of venlafaxine?

SNRI

12

What is the MOA of desvenlafaxine?

SNRI

13

What is the MOA of levomilnacipran?

SNRI

14

What is the MOA of fluoxetine?

SSRI

15

What is the MOA of fluvoxamine?

SSRI

16

What is the MOA of paroxetine?

SSRI

17

What is the MOA of sertraline?

SSRI

18

Which of the SSRIs can cause QTc prolongation?

Citalopram and escitalopram

19

What is the MOA of SNRIs?

Increase 5HT and NE

20

True or false: there is no such thing as a stronger or weaker antidepressant

True

21

What is the MOA of vilazodone?

SSRI with 5HT1 binding properties

22

What is the MOA of vortioxetine?

SSRI with multiple serotonin properties

23

What is the effect of vilazodone and vortioxetine on weight?

Weight neutral

24

What is the MOA of bupropion?

NE and dopamine reuptake inhibitor

25

What is the MOA of mirtazapine? What is it known for?

Alpha 2 blocker and serotonin blocker

Weight gain (good in cachectic patients)

26

What is the MOA of trazodone?

Inhibition of 5HT2A receptors. Human and animal studies have demonstrated that inhibition of this receptor is associated with antianxiety, antipsychotic and antidepressant effects.

27

What is the MOA of Quetiapine?

Atypical antipsychotic

28

What is methylphenidate?

Ritalin (amphetamine)

29

What is dextroamphetamine?

Adderall

30

Which gender has an increased prevalence in bipolar disorder?

Neither--equally common