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Flashcards in Somatic Therapies II Deck (61)
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1

What are the four major general classes of anxiolytics?

-Antidepressants
-benzos
-Buspirone
-Antihistamine

2

What are the antidepressants that are used to treat anxiety disorders? (3)

SSRIs
SNRIs
Mirtazapine

3

For treating OCD using SSRIs or clomipramine, what are the changes compared to treating depression?

-SSRIs need higher doses
-Need longer response time

4

What is the drug of choice for an acute panic attack? What is the major issue with this?

Alprazolam (xanax)

Fast onset, but short acting, and highly addictive because of that.

5

What is the only benzo that is absorbed IM?

Lorazepam

6

What are the side effects of benzos?

-Drowsiness
-Reduced motor coordination
-potential for tolerance

7

What are the withdrawal s/sx of benzos?

Like alcohol withdrawal

8

True or false: benzos have major adverse effects in pregnancy

False--generally safe PRN

9

True or false: benzos have adverse effects with breastfeeding

True

10

What is the MOA of buspirone? Use?

-5HT1a agonism
-Anxiolytic w/o sedation
-No risk of tolerance

11

True or false: buspirone is effective for treating OCD, but not panic attacks or phobias

False--not effective for any of them. Only GAD.

12

What is buspirone used for now?

Augment antidepressants for anxiety disorders

13

What is the general treatment regimen for anxiety?

-SSRIs
-SNRIs if SSRIs fail
-Mirtazapine

14

What is the role of benzos in the treatment of anxiety disorders?

Short term, acute episodes PRN

15

Is buspirone used PRN or long term?

Long term

16

What are the four major typical antipsychotics? Which is a weak one?

-Haloperidol
-Chlorpromazine**
-Thioridazine**
-Fluphenazine

17

What are the atypical antipsychotics? (6)

-Olanzapine
-Clozapine
-Quetiapine
-Risperidone
-Aripiprazole
-Ziprasidone

18

What is the general MOA of antipsychotics?

Postsynaptic D2 receptor blockade in the mesolimbic and mesocortical pathway

19

What are the uses of FGAs?

-Schizophrenia
-Psychosis
-Agitation
-Tourette's syndrome

20

What is the only antipsychotic that is not approved for use with schizophrenia? What is it used for?

Clozapine
Refractory schizophrenia

21

What is the use for risperidone that is unlike the other FGAs?

ASD

22

How fast are antipsychotics in treating agitation?

30-60 minutes

23

What organ metabolizes antipsychotics?

Liver

24

What is the duration of an adequate trial of antipsychotics?

4-6 weeks

25

What percent of pts taken off of antipsychotics for schizophrenia will relapse?

75%

26

True or false: prevention of relapse with schizophrenia is more important than side effects

True

27

What is the psychotic drug that causes agranulocytosis?

Clozapine

28

What is the psychotic drug that causes hyperprolactinemia? How?

Risperidone
Dopamine antagonism

29

What is neuroleptic malignant syndrome? S/sx?

Reaction to antipsychotics

-Fever
-Elevated CPK
-Vital sign instability
-Encephalopathy
-Rigidity

30

What is the treatment for NMS? (3)

-IVFs
-Dantrolene
-Bromocriptine or other dopamine agonist