Flashcards in Somatic Therapies III Deck (57)
What are the two drugs approved for bipolar maintenance?
What are the three drugs that are helpful for the depressive stage of bipolar disorder?
What is the onset of action of Li?
What organ metabolizes Li?
What is the WBC abnormality that can occur with Li use?
Demarginalization causing leukocytosis
True or false: Li is rapidly absorbed
What are the pharmacokinetics of Li?
What are the side effects of Li?
How often should Li levels be checked?
Monthly for 3 months, then q 3 months
What are the drugs that increase Li levels?
Na depleting diuretics
Where is Li reabsorbed in the kidney?
Long term use of Li can increase what lyte level?
What are the cognitive side effects of Li?
What are the congenital effects of Li?
Ebstein cardiac anomaly
When does Li toxicity come into play?
1.5 levels and above
What is the treatment for Li toxicity?
When is divalproex used for bipolar?
What is the MOA of divalproex?
Increase GABA by inhibiting degradation and stimulating synthesis
What organ metabolizes divalproex? What are the labs that are monitored?
What are the teratogenic effects of divalproex?
What are the side effects of divalproex?
What are the effects of divalproex in prego?
What is the MOA and use of carbamazepine?
-Acute mania and bipolar
-Na channel blocker and GABA agonist
What is the major side effect of carbamazepine?
What is the MOA and use of lamotrigine?
-Na channel blocker
What is the major side effect of lamotrigine? What must be done to prevent this?
-Start slow and titrate up
What is the role of topiramate and gabapentin in the treatment of bipolar disorder?
No evidence of efficacy
What are the three major first line drugs in the treatment of Bipolar disorder?
What is the role of SGAs in the treatment of bipolar disorder?