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Psychiatry pro +1700 > Neurocognitive Disorders > Flashcards

Flashcards in Neurocognitive Disorders Deck (87)
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1

What are the diagnostic criteria / domains for neurocognitive decline? (6)

Decline in:
-Language
-Complex attention
-Perceptual motor
-Executive function
-Learning and memory
-Social cognition

-(LAPELS)

2

What is the difference between major and minor cognitive decline?

Major = significant impairment

Minor = modest decline

3

Dementia is unusual to see prior to what age?

65

4

True or false: very few cases of dementia are reversible

True

5

What is the most common cause of dementia?

Alzheimer's disease

6

What areas of the brain (lobes) are affected with AD?

Parietal and temporal lobes

7

True or false: dementia is a normal part of aging

False

8

What are the genes that are associated with AD?

Presenilin 1 and 2
amyloid precursor protein

9

What is the gene that is associated with early onset AD?

ApoE4

10

What is the gene that is protective against AD?

Apo E2

11

True or false: early onset AD has a strong genetic component

True

12

What is the natural h/o AD?

Gradual onset and progression

13

What are the two major questions that are used to screen for AD?

-lost in a well known area
-Cannot pay bills

14

What is the neurotransmitter that is changed with AD?

Decreased ACh

15

What are the histological findings of AD?

-Neurofibrillary tangles
-Neuritic plaques
-Excess amyloid

16

What is the average survival rate of AD?

8-10 years

17

What is the function of the Tau proteins?

Maintaining neuronal function (microtubule associated proteins)

18

What areas of the brain are particularly affected with AD?

Hippocampus

19

What is Binswanger's disease? Which part of the brain is usually affected?

Multi Infarct dementia that is usually subcortical, but progresses to cortical dementia

20

What disease usually coexists with AD?

Vascular disease

21

What is the second most common type of dementia?

Vascular disease

22

What are the psychosis s/sx of lewy body dementia?

-Visual hallucinations/ delusions

23

What are the s/sx of PD? (TRAP)

-Tremor (resting)
-Rigidity
-Akinesia
-Postural instability

24

What is the treatment for lewy body disease? What should never be used?

Cholinesterase inhibitors

Never use antipsychotics

25

What is Pick's disease?

Frontotemporal dementia--selective atrophy that involved the temporal and/or frontal lobes of the brain

26

When does frontotemporal dementia usually present, relative to AD?

50s as opposed to 70s for AD

27

What are the first s/sx of frontotemporal dementia?

Disinhibition and language problems

28

When do s/sx of CTE usually present?

8-10 years following repeated concussions

29

What are the usual s/sx of CTE?

-Disorientation, HA
-Memory loss, poor judgement
-Progressive dementia

30

What is the major difference between cortical and subcortical dementia?

Cortical = global loss
Subcortical is not