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Flashcards in Somatic Therapies Deck (78)
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1

Why do antidepressants take a long time to work?

Need to increase receptors, and gene transcription

2

What is the MOA of imipramine? Use?

TCA
Enuresis

3

What is the MOA of bupropion?

NE and dopamine reuptake inhibitor

4

What is the MOA of venlafaxine?

SNRI

5

What is the MOA of desvenlafaxine?

SNRI

6

What is the MOA of duloxetine?

SNRI

7

What is the MOA of levomilnacipran?

SNRI

8

What are the two TCAs that are used to treat pain?

Amitriptyline
Nortriptyline

9

What is the only SSRI that is not approved for use in MDD? What is it used for?

-Fluvoxamine
-OCD

10

Which SSRI is used for bulimia?

Fluoxetine

11

Which SSRIs are used to treat GAD?

Escitalopram
Paroxetine

12

True or false: structurally, the SSRIs are structurally similar

False

13

What is the major side effect of bupropion?

Lowers seizure threshold

14

SSRIs are metabolized through what organ?

Liver

15

Which of the SSRIs have long lasting, active metabolites? (2)

-Fluoxetine
-Sertraline

16

What are the side effects of SSRIs?

-Weight gain or loss
-Vivid dreams
-mild GI symptoms

17

What is the treatment for serotonin syndrome?

Cyproheptadine

18

What is the effect of SSRIs and the p450 system?

Metabolized by it--cause drug interactions

19

What is the age range that SSRIs can cause increased suicidality?

up to 24

20

True or false: there is no evidence that there is an increased in actual suicide with antidepressants, just thoughts

True

21

What are the s/sx of serotonin syndrome?

-Diaphoresis
-Mental confusion
-Flushing
-Hyperthermia
-Hypertonicity

22

True or false: SNRIs inhibit both NE and 5HT in equal amounts

True

23

What is the SNRI that has been approved for MDD, GAD, panic DO, SAD, pain syndrome?

Venlafaxine

24

What is the effect of venlafaxine at higher and lower doses?

Lower = 5HT reuptake inhibition

Higher = NE and dopamine

25

What is the effect of venlafaxine an p450 enzymes?

Does not use the p450 system

26

What is the major downside of venlafaxine withdrawal?

fast onset

27

What is the MOA of levomilnacipran?

SNRI

28

What is the role of bupropion in the treatment for anxiety disorders?

Not effective

29

Why is it that bupropion may test positive for amphetamine use?

Similar structure

30

What is the effect of bupropion on sexual function?

No effect