HEMA 2 LEC - Mature Lymphoid Neoplasms 3

Question 1

• Large atypical cells with pleomorphic nuclei and abundant cytoplasm.

Answer 1

Anaplastic Large Cell Lymphoma

Question 2

• Expression of CD30 antigen and ALK protein

Answer 2

Anaplastic Large Cell Lymphoma

Question 3

• If with fibrosis: anaplastic large cell lymphoma may resemble ____

Answer 3

Hodgkin lymphoma

Question 4

t(2;5)(p23;35) between the ALK and nucleophosmin genes

Answer 4

Anaplastic Large Cell Lymphoma

Question 5

t(2;5)(p23;35)

Answer 5

Anaplastic Large Cell Lymphoma

Question 6

• Pan–T-cell markers (CD3, CD7, CD5): often absent

Answer 6

Anaplastic Large Cell Lymphoma

Question 7

• Proportion of cells are large with abundant cytoplasm and pleomorphic, eccentric, kidney-shaped nuclei, so-called hallmark cells

Answer 7

Anaplastic Large Cell Lymphoma

Question 8

Cells found in Anaplastic Large Cell Lymphoma

large with abundant cytoplasm and pleomorphic, eccentric, kidney-shaped nuclei

Answer 8

Hallmark cells

Question 9

• One of the most common lymphomas in the pediatric population (10% to 15% of childhood lymphomas) disseminated nodal disease with constitutional symptoms

Answer 9

Anaplastic Large Cell Lymphoma

Question 10

most important prognostic feature of Anaplastic Large Cell Lymphoma

Answer 10

expression of ALK protein

Question 11

___disease has a favorable prognosis: ALK+ or ALK-

Answer 11

ALK+

Question 12

___disease shows survival rates more comparable to those for peripheral T-cell lymphoma, unspecified: ALK+ or ALK-

Answer 12

ALK-

Question 13

2 categories of Hodgkin lymphoma

Answer 13

o Nodular lymphocyte-predominant Hodgkin lymphoma

o Classical Hodgkin lymphoma

Question 14

• B-cell neoplasm composed of relatively rare neoplastic cells (lymphocytic/histiocytic or “popcorn” cells) scattered within nodules of reactive lymphocytes

Answer 14

Nodular lymphocyte-predominant Hodgkin lymphoma

Question 15

do cells of Nodular lymphocyte-predominant Hodgkin lymphoma show EBV infection

Answer 15

No

Question 16

• heterogenous group of lymphoid neoplasms derived from the germinal center.
• presence of relatively few diagnostic neoplastic cells, Reed-Sternberg cells, in a rich reactive background

Answer 16

Classical Hodgkin Lymphoma

Question 17

in the United States and Europe, it is a common form of lymphoma occurring in young adults

Answer 17

Classical Hodgkin Lymphoma

Question 18

subtypes of Classical Hodgkin Lymphoma (4)

Answer 18

1. Nodular sclerosis
2. Mixed cellularity

3. Lymphocyte rich

4. Lymphocyte depleted

Question 19

what cells are present in all subtypes of classical Hodgkin lymphoma

Answer 19

reed-sternberg cells

Question 20

large lymphoid cell with a bilobed nucleus or two nuclei with prominent eosinophilic nucleoli and abundant cytoplasm (what cell which is present in classical Hodgkin lymphoma)

Answer 20

reed-sternberg cells

Question 21

what cell is pathognmonic for Classical Hodgkin Lymphoma

Answer 21

reed-sternberg cells

Question 22

variants of reed-sternberg cells
large mononuclear lymphoid cells with an oval nucleus, thick nuclear membrane, distinct eosinophilic nucleolus, and abundant cytoplasm

Answer 22

Hodgkin cells

Question 23

variants of reed-sternberg cells - degenerated or apoptotic cells with a pyknotic nucleus and condensed cytoplasm

Answer 23

Mummified cells

Question 24

variants of reed-sternberg cells - occur predominantly in the nodular sclerosis variant of classical Hodgkin lymphoma and are characterized by a lobated nucleus and artifactual retraction of the cytoplasm secondary to formalin fixation. Because of this artifact, the cells appear to be situated in a clear space

Answer 24

Lacunar cells

Question 25

which category of hodgkin lymphoma show EBV infection

Answer 25

classical hodgkin lymphoma

Question 26

what subtype of classical hodgkin lymphoma | presence of broad collagen bands transecting the lymph node, thickening of the nodal capsule and lacunar cells

Answer 26

Nodular sclerosis classical Hodgkin lymphoma

Question 27

most common of all the subtypes of classical Hodgkin lymphoma, accounting for 70% of cases

Answer 27

Nodular sclerosis classical Hodgkin lymphoma

Question 28

what subtype of classical hodgkin lymphoma | background cellularity includes small lymphocytes, eosinophils, and histiocytes

Answer 28

Nodular sclerosis classical Hodgkin lymphoma

Question 29

what subtype of classical hodgkin lymphoma | • frequency of immunohistochemically demonstrable EBV infection is lowest in this variant

Answer 29

Nodular sclerosis classical Hodgkin lymphoma

Question 30

what subtype of classical hodgkin lymphoma Reed-Sternberg cells and their variants scattered among the diffuse background proliferation of small lymphocytes, histiocytes, eosinophils, neutrophils, and plasma cells.

Answer 30

Mixed cellularity classical Hodgkin lymphoma

Question 31

what subtype of classical hodgkin lymphoma Typical Reed-Sternberg cells, mononuclear Hodgkin cells, and mummified cells are seen; however, lacunar cells are absent.

Answer 31

Mixed cellularity classical Hodgkin lymphoma

Question 32

what subtype of classical hodgkin lymphoma | fibrotic bands and capsular thickening are not seen

Answer 32

Mixed cellularity classical Hodgkin lymphoma

Question 33

what subtype of classical hodgkin lymphoma | Scattered mononuclear Hodgkin and Reed-Sternberg cells seen along with a vaguely nodular background of small lymphocytes

Answer 33

Lymphocyte-rich classical Hodgkin lymphoma

Question 34

what subtype of classical hodgkin lymphoma | Nodules represent remnants of mantle zones and residual germinal centers

Answer 34

Lymphocyte-rich classical Hodgkin lymphoma

Question 35

what subtype of classical hodgkin lymphoma | Background cellularity is less heterogeneous

Answer 35

Lymphocyte-rich classical Hodgkin lymphoma

Question 36

what subtype of classical hodgkin lymphoma | Uncommon variant of classical Hodgkin lymphoma

Answer 36

Lymphocyte-depleted classical Hodgkin lymphoma

Question 37

what subtype of classical hodgkin lymphoma Predominant in immunodeficient patients

Answer 37

Lymphocyte-depleted classical Hodgkin lymphoma

Question 38

what subtype of classical hodgkin lymphoma Scarcity (paucity) of cells of reactive background

Answer 38

Lymphocyte-depleted classical Hodgkin lymphoma

Question 39

what subtype of classical hodgkin lymphoma Neoplastic Reed-Sternberg cells and their variants are much more frequent • Cells show evidence of EBV infection

Answer 39

Lymphocyte-depleted classical Hodgkin lymphoma

Question 40

only subtype of classical Hodgkin lymphoma which occurs in slightly older population (because majority: young adults)

Answer 40

lymphocyte-rich variant

Question 41

only subtype of classical Hodgkin lymphoma which does not involve peripheral lymph node

Answer 41

nodular sclerosis

Question 42

subtype of classical Hodgkin lymphoma which shows mediastinal lymphadenopathy

Answer 42

nodular sclerosis

Question 43

subtype of classical Hodgkin lymphoma which | with the best prognosis

Answer 43

nodular sclerosis

Question 44

subtype of classical Hodgkin lymphoma which is the most aggressive variant of classical Hodgkin lymphoma especially in HIV-positive patients

Answer 44

Lymphocyte-depleted Hodgkin lymphoma