SI LEC - Innate Immunity Part 2

Question 1

Serum Amyloid A assoc with

Answer 1

HDL-Cholesterol

Question 2

Apolipoprotein

MW = ??

Answer 2

11, 685 daltons

Question 3

Normal circulating levels of SAA

Answer 3

30 µg/mL

Question 4

Functions of SAA

Answer 4

Cleaning up chole from macrophages at the site of tissue injuries
Recycles cell membrane cholesterol

Question 5

Series of serum proteins that are normally present
Major functions include:
	  opsonization
     chemotaxis
     cytolysis

Answer 5

Complement

Question 6

complement Major functions include:

Answer 6

opsonization
chemotaxis
cytolysis

Question 7

Mannose-Binding Protein also called

Answer 7

Aka mannose-binding lectin

Question 8

Trimer
Acts as an opsonin
Ca-dependent

Answer 8

Mannose-Binding Protein

Question 9

Recognize foreign CHO found on bacteria, yeasts, viruses, parasites

Answer 9

Mannose-Binding Protein

Question 10

Activates C’, helps promote phagocytosis

Answer 10

Mannose-Binding Protein

Question 11

Normal concentration = of MBP

Answer 11

10 µg/mL

Question 12

Uninhibited proteases can remain in lower resp tract and destroy parenchymal cells = development of ___

Answer 12

emphysema

Question 13

endogenous ENZ that degrade elastin and collagen

Answer 13

Elastase :

Question 14

Major component of the alpha band in SPE

Plasma inhibitor of proteases released from WBC (eg. elastase)

Answer 14

Alpha1-antitrypsin

Question 15

Acts a “mop-up” or counteracts the effect of neutrophil invasion during inflammation

Answer 15

Alpha1-antitrypsin

Question 16

Can also react w/ serine proteases triggering C’ cascade or fibrinolysis

Answer 16

Alpha1-antitrypsin

Question 17

Regulates expression of pro-inflammatory cytokines

Answer 17

Alpha1-antitrypsin

Question 18

An Alpha2- globulin

Answer 18

haptoglobin

Question 19

MW of haptoglobin

Answer 19

100 000

Question 20

Binds free hgb (released by intravascular hemolysis) irreversibly

Answer 20

haptoglobin

Question 21

Hgb Haptoglobin complex cleared by

Answer 21

liver

Question 22

haptoglobin levels may ___ because of intravascular hemolysis: must be interpreted in the light of other APR

Answer 22

drop

Question 23

Normal plasma conc= 40 to 290 mg/dL what acute reactant protein

Answer 23

haptoglobin

Question 24

haptoglobin Normal plasma conc

Answer 24

40 to 290 mg/dl

Question 25

Unfolded CHONS __ in blood vessels

Answer 25

aggregate

Question 26

plays a role in protecting kidneys from damage

Answer 26

haptoglobin

Question 27

prevents loss of iron

Answer 27

haptoglobin

Question 28

prevents oxidative damage of free hgb

Answer 28

haptoglobin

Question 29

Most abundant coagulation factor

Answer 29

fibrinogen

Question 30

Normal levels= 100 to 400 mg/dL

Answer 30

fibrinogen

Question 31

forms fibrin clots

Answer 31

Fibrinogen

Question 32

trimer

Answer 32

mannose-binding protein

Question 33

dimer

Answer 33

fibrinogen

Question 34

fibrinogen normal levels

Answer 34

100 to 400 mg/dl

Question 35

MW = 340, 000 daltons

Answer 35

fibrinogen

Question 36

MW of fibrinogen

Answer 36

340 000

Question 37

Increases the strength of the wound

Answer 37

Fibrinogen

Question 38

Promotes aggregation of RBCs | can increased risk of developing CAD

Answer 38

Fibrinogen

Question 39

Forms a clot; a barrier to prevent spread of microbes

Answer 39

Fibrinogen

Question 40

Stimulates endothelial cell adhesion and proliferation

Answer 40

Fibrinogen

Question 41

autosomal recessive genetic disorder | Co accumulates in the liver, brain, cornea, kidneys,

Answer 41

Wilson’s dx

Question 42

Acts as ferroxidase

Answer 42

Ceruloplasmin

Question 43

the principal Co-transporting protein in the human plasma

Answer 43

Ceruloplasmin

Question 44

MW= 132, 000 daltons

Answer 44

Ceruloplasmin

Question 45

Binds 90-95% copper found in the plasma

Answer 45

Ceruloplasmin

Question 46

help make neutrophils sticky and enhance adherence to endothelial cells

Answer 46

Selectins:

Question 47

movement thru blood vessel walls.

Answer 47

diapedesis

Question 48

NEUT form __ which squeeze thru junctions

Answer 48

pseudopods

Question 49

chem’l messenger that cause cells to migrate in a particular direction

Answer 49

chemotaxins

Question 50

Life span of neutrophil in the tx:

Answer 50

5 days

Question 51

w/ primary and specific granules Capable of phagocytosis but not as efficient as neutrophil Neutralizing basophils and mast cells Killing parasites

Answer 51

Eosinophils

Question 52

vasoactive amine that contracts smooth muscle

Answer 52

Basophils

Question 53

immunoglobulin that binds to surface of basophil

Answer 53

IgE

Question 54

lifespan of basophils

Answer 54

few hours

Question 55

Basophils that have migrated to the tissues.

Answer 55

Mast Cells

Question 56

Largest in the peripheral blood

Answer 56

Monocytes

Question 57

granules of monocytes (6)

Answer 57

``` peroxidase ACP arylsulfatase beta-glucuronidase lysozyme lipase ```

Question 58

monocytes Stay in peripheral blood up to ?? hours

Answer 58

70

Question 59

as macrophage become monocytes, there is an increase in __

Answer 59

Increase in ER, lysosomes, and mitochondria

Question 60

w/ progressive cellular enlargement to b/w 25-80 um

Answer 60

tissue macrophage

Question 61

Long lived but slow in motility

Answer 61

monocytes

Question 62

Fxn: microbial killing, tumoricidal, intracellular parasites eradication, phagocytosis, secretion of cytokines, Ag presentation

Answer 62

monocytes

Question 63

main fxn of dendritic cells

Answer 63

Phagocytose Ag and present in T helper cells