pharmaco - chapter 7 - final

Question 1

 Mimic acetylcholine

Answer 1

CHOLINOMIMETIC DRUGS

Question 2

 Permanently charged quaternary NH4 group
 Relatively insoluble in lipids
 Poorly absorbed
 Poorly distributed in the CNS
 Hydrophilic
 Hydrolyzed in the GIT
 Differ markedly in their susceptibility to hydrolysis by cholinesterase

Answer 2

choline esters

Question 3

type of choline ester

 Very rapidly hydrolyzed
 Large amounts must be infused IV to achieve concentrations high enough to produce detectable effects

Answer 3

ACETYLCHOLINE