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Flashcards in Developmental Aspects of Lung Disease Deck (71)
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1

What is morphogenesis?

The origin and development of morphological characteristics

2

What is morphology?

Branch of biology dealing with the study of the form and structure of organisms

3

What are the stages of lung morphogenesis?

1) Embryonic (3-8 weeks)

2) Pseudo-glandular (5-17 weeks)

3) Canalicular (16-26 weeks)

4) Saccular (24-38 weeks)

5) Alveolar (36 weeks - 2/3 years)

4

When is the embryonic stage of lung morphogenesis?

3-8 weeks

5

When is the pseudo-glandular stage of lung morphogenesis?

5-17 weeks

6

When is the canalicular stage of lung morphogenesis?

16-26 weeks

7

When is the succular stage of lung morphogenesis?

24-38 weeks

8

When is the alveolar stage of lung morphogenesis?

36 weeks - 2/3 years

9

What stage of lung morphogenesis is this?

Embryonic

10

What stage of lung morphogenesis is this?

Pseudo-glandular

11

What happens to the alveoli after birth?

They continue to seperate

12

How many alveoli are there at birth compared to at 3-8 years?

100-150 million at birth

200-600 million at 3-8 years

13

What happens to alveolar dimensions as children age?

They increase

14

What happens during the embryonic and pseudo-glandular stages?

Formation of major airways

Formation of bronchial tree and portions of respiratory parenchyma

Birth of the acinus

15

What happens during the canalicular stage?

Last generation of the lung periphery formed

Epithelial differentiation

Air blood barrier formed

16

What happens during the saccular stage?

Expansion of air spaces

Surfactant detectable in amniotic fluid

17

What happens during the alveolar stage?

Secondary seperation

18

When are presenting problems found?

Foetal ultrasound (75%)

Childhood (15%)

Newborn (10%)

 

19

What presenting problems are detected in a newborn?

Trachypnoea (abnormally rapid breathing)

Respiratory distress

20

What is trachypnoea?

Abnormally rapid breathing

21

What is abnormally rapid breathing called?

Trachypnoea

22

What problems are often detected in childhood?

Wheeze/stridor

Recurrent pneumonia (same region of the lung)

Incidental finding

23

What is congenital?

A disease present from birth

24

What is a disease present from birth known as?

Congenital

25

What are some common congenital lung diseases?

Tracheo-bronchomalacia

Pulmonary adenomatoid malformation

26

What are symptoms of tracheo-bronchomalacia?

Barking cough

Early onset

Breathless on exertion

Stridor/wheeze

27

What is the management of tracheo-bronchomalacia?

Airway clearance physiotherapy

Antibiotics

Avoid asthma treatment

28

What is trachea-bronchomalacia?

Uncommon disease of the central airways resulting from softening or damage of the cartilaginous structures of the airway walls in the trachea and bronchi

29

What is pulmonary adenomatoid malformation?

Usually an entire lobe of lung is replaced with is replaced with a non-working cystic piece of abnormal lung tissue

30

When does closure of the diaphragm occur?

About 18 weeks