Pathology 5 - Chronic Inflammation Flashcards Preview

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Flashcards in Pathology 5 - Chronic Inflammation Deck (22)
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What is chronic inflammation?

Chronic response to injury with associated fibrosis


How may chronic inflammation arise?

- may take over from acute inflammation (if damage is too severe to be resolved quickly)
- can arise de novo (in some autoimmune conditions, some chronic infections)
- may develop alongside acute inflammation (in severe persistent/repeated irritation)


Why is the appearance of chronic inflammation much more variable than that of acute inflammation?

It is characterised more by the type of cell present, which can vary


What are macrophages derived from?

Blood monocytes


What are the functions of macrophages?

- PHAGOCYTOSIS (+ destruction of debris and bacteria)
- processing and PRESENTATION OF ANTIGEN to immune system
- SYNTHESIS of cytokines, complement components, blood clotting factors and proteases
- CONTROL of other cells via cytokine release


What are the functions of lymphocytes?

- complex and usually immunological
- B-lymphocytes differentiate to produce antibodies
- T-lymphocytes involved in control and cytotoxic functions


What are plasma cells?

Differentiated antibody-producing B lymphocytes. These usually imply that the condition is chronic


In what situations would lots of eosinophils be found in the body?

Allergic reactions, parasite infestations, some tumours


What is the function of fibroblasts/myofibroblasts?

They are recruited by macrophages and make collagen


What are 'giant' cells?

Multinucleate cells made by fusion of macrophages due to 'frustrated phagocytosis'


What are the three types of giant cell?

- Langhans (tuberculosis)
- Foreign Body Type
- Touton (fat necrosis)


What are the effects of chronic inflammation?

- fibrosis
- impaired function
- atrophy
- stimulation of immune response


What is chronic cholecystitis?

Repeated obstruction of the gall bladder by gall stones. Repeated acute inflammation leads to chronic inflammation and therefore fibrosis of the gall bladder wall.


What is inflammatory bowel disease?

An idiopathic inflammatory disease affecting the large and small bowel. Patients have diarrhoea, rectal bleeding and other symptoms. May be caused by ulcerative colitis (which causes diarrhoea and bleeding) or Crohn's disease (which causes strictures and fistulae)


Give some common causes of cirrhosis

- alcohol
- infection with HBV or HCV
- immunological
- fatty liver disease
- drugs and toxins
- obesity


Give an example of a condition causing increased function as a result of chronic inflammation

Graves disease causes hyperthyroidism


True or false - chronic inflammation and immune responses are very separate?

False - they often overlap


What is a granuloma?

A small, nodular aggregation of inflammatory cells that stick together


What is granulomatous inflammation?

Chronic inflammation with granuloma formation


Give some causes of granulomatous inflammation

- irritant 'foreign' material
- infections by mycobacteria, such as tuberculosis or leprosy
- unknown causes such as sarcoid, Wegener's granulomatosis, Crohn's disease


True or false - Tuberculosis produces no toxins or lytic enzymes?



What is the rough structure of a tuberculous granuloma?

A circle of epithelioid histiocytes surrounded by lymphocytes, with a patch of caseous necrosis in the centre. There may be giant Langhans cells present

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