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Flashcards in Acute Inflammation 2 Deck (57)
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1

What is inflammation named according to?

The anatomical location if occurs at

2

How is inflammation named?

'Structure'-itis

Such as:
Peritonitis (perioneal cavity)
Meningitis (meninges)
Appendicitis (appendix)

 

Except for:
Lungs
Pleural cavity

3

What is inflammation of the lungs known as?

Pneumonia

4

What is inflammation of the pleural cavity known as?

Pleurisy

5

What is the process of neutrophils destroying pathogens?

1) Recognise foreign anitgens

2) Move towards it

3) Adhere to it

4) Release oxidants (such as hydrogen peroxide) and enzymes (such as proteases) and destroy the pathogen

6

What is the consequence of neutrophil action?

Once they die they release their granules, producing pus which might extend to other tissues and cause further inflammation

7

What is pus?

A soup of fluids, containing bits of cells, organisms and endogenous proteins

8

What are the main plasma proteins in inflammation?

Fibinogen

Immunoglobulin

9

What is the role of fibrinogen?

Forms fibrin and clots exudate (localising the process)

10

What is the role of immunoglobulins?

Specific for antigen, humoral immune response

11

What are mediators of acute inflammation?

Molecules on endothelial cell surface

Molecules released from cells

Molecules in the plasma

Molecules inside cells

12

What are the collective effect of mediators?

Vasodilation

Increased permeability

Neutrophil adhesion

Chemotaxis (movement of motile cell)

Itch and pain

13

What is chemotaxis?

Movement of motile cell

14

What helps neutrophils stick?

Cell surface mediator ICAM-1 which appears on endothelial cells

15

What are mediators released from cells?

Histamine

Serotonin

Prostglandins

Cytokines

Nitric oxide

Oxygen free radicals

16

What cells release histamine?

Mast cells

Platelets

Basophils

17

What does histamine cause?

Vasodilation

Increased permeability

18

What releases serotonin?

Plateletes

19

What does serotonin do?

Causes vasoconstriction

20

What do prostgandlins do?

Promote histamine effect

Inhibit inflammatory cells

21

What produces cytokines?

Macrophages

Lymphocytes

Endothelium

22

What effects do cytokines have?

Both pro and anti-inflammatory

23

What do cytokines do?

Stimulate extracellular pathways and signilling

24

What does nitric acid do?

Smooth muscle relaxation

Anti-platelet

Regulate lymphocyte recruitment

25

What releases oxygen free radicals?

Neutrophils on phagocytosis

26

What do oxygen free radicals do?

Amplify other mediatory effects

27

What are molecules released inside cells for?

Signilling

28

What do are mediators released inside the cell?

Pathogen associated molecular pattern

Danger associated molecular pattern

29

What do mediators released inside the cell do?

Activate inflammatory response

30

What are the 4 purposes of plasma molecules?

Blood coagulation pathways

Fibrinolysis

Kinin system

Compliment cascade