What is inflammation named according to?
The anatomical location if occurs at
How is inflammation named?
Peritonitis (perioneal cavity)
What is inflammation of the lungs known as?
What is inflammation of the pleural cavity known as?
What is the process of neutrophils destroying pathogens?
1) Recognise foreign anitgens
2) Move towards it
3) Adhere to it
4) Release oxidants (such as hydrogen peroxide) and enzymes (such as proteases) and destroy the pathogen
What is the consequence of neutrophil action?
Once they die they release their granules, producing pus which might extend to other tissues and cause further inflammation
What is pus?
A soup of fluids, containing bits of cells, organisms and endogenous proteins
What are the main plasma proteins in inflammation?
What is the role of fibrinogen?
Forms fibrin and clots exudate (localising the process)
What is the role of immunoglobulins?
Specific for antigen, humoral immune response
What are mediators of acute inflammation?
Molecules on endothelial cell surface
Molecules released from cells
Molecules in the plasma
Molecules inside cells
What are the collective effect of mediators?
Chemotaxis (movement of motile cell)
Itch and pain
What is chemotaxis?
Movement of motile cell
What helps neutrophils stick?
Cell surface mediator ICAM-1 which appears on endothelial cells
What are mediators released from cells?
Oxygen free radicals
What cells release histamine?
What does histamine cause?
What releases serotonin?
What does serotonin do?
What do prostgandlins do?
Promote histamine effect
Inhibit inflammatory cells
What produces cytokines?
What effects do cytokines have?
Both pro and anti-inflammatory
What do cytokines do?
Stimulate extracellular pathways and signilling
What does nitric acid do?
Smooth muscle relaxation
Regulate lymphocyte recruitment
What releases oxygen free radicals?
Neutrophils on phagocytosis
What do oxygen free radicals do?
Amplify other mediatory effects
What are molecules released inside cells for?
What do are mediators released inside the cell?
Pathogen associated molecular pattern
Danger associated molecular pattern
What do mediators released inside the cell do?
Activate inflammatory response
What are the 4 purposes of plasma molecules?
Blood coagulation pathways