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Principles of Disease > Drug Delivery Systems > Flashcards

Flashcards in Drug Delivery Systems Deck (48)
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1

What are different kinds of drug delivery?

Oral

Intravenous (IV)

Transdermal

Carrier based

2

What are different forms of drugs that may be given to patients?

Tablets or capsules

Solutions or suspensions

Ointments and creams

Inhalation

Injections

Suppositories (insterted into rectum or vagina)

Pessaries (inserted into vagina)

3

What are soppositories?

Drugs that are inserted into the rectum or the vagina

4

What are pessaries?

Drugs that are inserted into the vagina

5

What are things that determine which drug delivery system to use?

Dose of the drug being given

Frequency of administration

Timing of administration

Disease being treated

6

What do we consider when deciding what dose to use?

Recommended dose

Impaired renal function

Impaired liver function

Age and weight

Disease to be treated

Drug toxicity

7

What is oral medication absorbed by?

The GI tract:

 

Buccal

Sublingual

Oral

Rectal

8

What are solutions and suspension useful for?

Giving medicine to the young, elderly and patients with swollowing difficulties

9

What is an advantage of using solutions or suspensions?

Absorbed extrememly rapidly

10

What does the absorption of solutions or suspensions depend on?

Gastric emptying and is more rapid from the small intestine

11

Where is absorption from solutions or suspensions most rapid from?

Small intestine

12

What is the rate limiting step for the absorption of tablets?

Dissolution (tablet breakdown)

13

What are the advantages of using tablets or capsules?

Convenience

Accuracy of dose

Reproducibility

Drug stability

Ease of mass production

14

What do enteric coated tablets do?

Delay the disintegration of the tablet until it reaches the small instestine

15

Why would enteric coated tablets be used?

Protect the drug from stomach acid

Protect the stomach from the drug

16

What are prolonged release formulations useful for?

Most disorders required prolonged therapy

Maintains drug level within a therapeutic range

Reduces the need for frequent dosing

Compliance is improved

17

What kind of therapy do most disorders require?

Prolonged therapy

18

What are different kinds of prolonged release drugs?

Oral preparations

Parenteral preparations (intermuscular injections)

Surgical implants

19

What can you not do when using prolonged release drugs?

Swap someone from one form to another

20

What are prodrugs?

Synthesised inactive derivatives of an active drug which requires to be metabolically activated after administration

21

What are the advantages of using prodrugs?

Prolongation of duration of action

Avoidance of the drug in the gut

22

What are buccal and sublingual adminstration ideal for?

Drugs which have an extensive first pass metabolism

23

What are sublingual tablets?

Ones which dissolve slowly under the tongue

24

Who is the rectal route often used for?

Young

Old

Patients unable to swollow

25

What is an advantage of using the rectal route?

Bypass first pass metabolism

26

How may drugs from the rectal route act?

Locally

Systematically

27

How do drugs from the vaginal route act?

Locally

28

What do drugs from the vaginal route include?

Creams

Pessaries

29

What do injection based drug delivery systems include?

Intravenous (IV)

Intramuscular

Subcutaneous

Intradermal

30

What do injection based drugs provide?

Fast systematic effects by bypassing first pass metabolism