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Flashcards in Drug Interactions Deck (64)
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1

What is a drug interaction?

Modification of a drugs effect by prior or concomitant administration of another drug

2

What are different things involved in drug interactions?

Drugs

Herbal

Food

Drinks

Pharmacogenetics

3

What is the object drug?

Drug which is effected by these interactions

4

What is the precipitant?

Agent which precipitants such a reaction

5

What are examples of drug interactions which are not always decremental?

Hypertension

Parkinson's

6

What is epidermiology?

Branch of medicine that deals with incidence, distribution and possible control of disease

7

What is the incidence of significant interactions?

Relatively low at 1%

8

What are some examples of drug involved in serious reactions?

Lithium

Warfarin

Erythromycin

Linezolid

9

What are drugs involved in serious interactions often?

Potent with a narrow therapeutic index, meaning a small change in blood levels induce toxicity

10

What do lots of foods interact with?

Warfarin

11

What happens to the probability of a drug-drug interaction with more medicaments?

Increases exponentially

12

Who are some people more likely to suffer from a drug-drug interaction?

Elderly

Young

Critically ill

Patients undergoing complicated surgery procedures

Patients on many medications

13

What kinds of conditions make people susceptable to drug interactions?

Chronic

14

What are examples of chronic conditions that make people more susceptable to drug interactions?

Liver disease

Renal impairment

Diabetes mellitus

Epilepsy

Asthma

15

Who usually experience severe interactions?

Patients with chronic conditions

16

What is pharmacodynamics?

Study of how a drug affects an organism

17

What is pharmacokinetics?

Study of how the organism affects the drug

18

What can drug interactions be?

Additive or synergistic

Antagonistic

19

What can interactions be due to?

Changes in drug transport

Fluid and elctrolyte disturbances

Indirect pharmacodynamics interactions

20

What are the 4 stages of pharmacodynamics?

Absorption

Distribution

Metabolism

Elimination

21

What can a drug do to the pharmacokinetics of another drug?

Alter it

22

Why is it possible to predict potential interactions?

Due to marked inter-individual variations in pharmacodynamics process

23

What is it not possible to predict?

Patients who will have a clinically significant interaction

24

What do absorption interactions mechanisms include?

Formation of insoluble complexes

Altered pH

Altered bacterial flora

Altered GIT motility

25

What do most absorption interactions lead to?

Change in absorption rate and not the extend of absorption

26

When is delayed absorption likely to have a great impact?

When the drug has a short half life or when we want high plasma levels quickly

27

How can absorption interactions be avoided?

2-4 hours are left between administration of drugs

28

What do some drugs do in the GI tract?

Bind to each other

29

What are examples of drugs that bind to each other in the GI tract?

Tetracycline and erythromycin complex with iron, calcium and magnesium

Cholestryamine resin used to bind cholesterol in the GI tract also binds to other drugs like warfarin

30

What is absorption affected by (relates to acids/bases)?

Degree of ionisation which is dependant on pH