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Flashcards in Thombosis Deck (68)
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1

What is the lining of an artery composed of?

Several endothelial cell, making a basal lamina to 'sit on'

2

What is found around the basal lamina of an artery?

Smooth muscle cells

3

What is found around the smooth muscle cells around an artery?

Interstitial collagen fibres

4

What is the middle of an artery called?

Lumen

5

What does the lumen of an artery contain?

Red blood cells

White blood cells

Platelets

Plasma

6

What is the colour of platelets and what size are they?

White and small

7

What are platelets not normally exposed to which is important in terms of thrombosis?

Interstitial collagen fibres

8

What does the plasma consist of?

Water

Numerous proteins

Clotting factors

Other molecules

9

What is serum?

Plasma without clotting factors

10

Where are clotting factors produced?

Liver or by epithelial cells

11

How are clotting factors named?

With a roman number, such as Factor VII

12

What kind of system are clotting factors?

Amplification system resulting in thrombin production

13

What do clotting factors result in the formation of?

Thrombin

14

What does thrombin do?

Converts soluble fibrinogen into insoluble fibrin

15

What is the process of damage to the formation off fibrin known as?

Clotting cascade which is an amplification system

16

What does TP stand for in terms of clotting?

Tissue factor

17

What is the basic process of the formation of fibrin?

1) Damage to vessel

2) Tissue factor is exposed

3) Tissue factor combines with clotting factor to convert prothrombin into thrombin

4) Thrombin converts fibrinogen into fibrin

18

What could the initial damage of the vessel be due to?

Trauma

19

What does trauma causing vessel damage lead to?

1) Exposure of interstitial collagen

2) Exposure of molecule called a tissue factor

3) Blood leaks out and the serum comes into contact with the interstitial collagen fibres, where plasma clotting factors are activated

20

What is interstitial collagen?

Collagen in connective tissues between structures

21

22

Where are tissue factors released from?

Smooth muscle cells

23

What exposes and releases tissue factors from smooth muscle cells?

Trauma

24

What does the tissue factor do?

Binds to the clotting factor and initiates the clotting cascade

25

What are many clotting factors?

Serine proteases, which have serine amino acids in them and they cleave other clotting factors to form the active molecules

26

What do many clotting factors do?

Cleave other clotting factors to form the active molecule

27

What is the difference between fibrin and fibrinogen?

Fibrinogen is a small soluble molecule, whereas fibrin is a large aggregate of insoluble strands

28

What is the end point of the clotting cascade?

The formation of fibrin from fibrinogen

29

Where are platelets produced?

In bone marrow

30

What cells are platelets formed from?

Megakaryocyte